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A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission.
TLDR
Evidence is presented that performance measures can validly characterize older persons across a broad spectrum of lower extremity function and that performance and self-report measures may complement each other in providing useful information about functional status. Expand
Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia.
TLDR
Older persons with anemia are common, albeit not severe, in the older population, and a substantial proportion of anemia is of indeterminate cause, which must be further investigated in older persons. Expand
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
TLDR
Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity. Expand
The FNIH Sarcopenia Project: Rationale, Study Description, Conference Recommendations, and Final Estimates
TLDR
Based on the analyses presented in this series, the final recommended cutpoints for weakness are grip strength <26kg for men and <16kg for women, and for low lean mass, appendicular lean mass adjusted for body mass index <0.789 forMen and women. Expand
Frailty consensus: a call to action.
TLDR
For the purposes of optimally managing individuals with physical frailty, all persons older than 70 years and all individuals with significant weight loss (>5%) due to chronic disease should be screened for frailty. Expand
Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery.
TLDR
Performance tests of lower extremity function accurately predict disability across diverse populations and Equations derived from models using both the summary score and the gait speed alone allow for the estimation of risk of disability in community-dwelling populations and provide valuable information for estimating sample size for clinical trials of disability prevention. Expand
Gait speed and survival in older adults.
TLDR
In this pooled analysis of individual data from 9 selected cohorts, gait speed was associated with survival in older adults and predicted survival was as accurate as predicted based on age, sex, use of mobility aids, and self-reported function. Expand
Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia.
TLDR
Optimal cutoff values that can be used in the clinical practice to identify older persons with poor mobility were developed and lay the basis for a cost-effective, clinical marker of sarcopenia based on a measure of isometric handgrip strength. Expand
Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis.
TLDR
Measurement of the ABI may improve the accuracy of cardiovascular risk prediction beyond the FRS, and is associated with approximately twice the 10-year total mortality, cardiovascular mortality, and major coronary event rate compared with the overall rate in each FRS category. Expand
Phenotype of frailty: characterization in the women's health and aging studies.
TLDR
The frailty definition developed in the CHS is applicable across diverse population samples and identifies a profile of high risk of multiple adverse outcomes and is consistent with the widely held theory that conceptualizes frailty as a syndrome. Expand
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