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Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations.
FOXO1A and FOXO3A are two members of the FoxO family. FOXO3A has recently been linked to human longevity in Japanese, German and Italian populations. Here we tested the genetic contribution of FOXO1A… Expand
The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens
Microbial pathogens use a variety of their surface molecules to bind to host extracellular matrix (ECM) components to establish an effective infection. However, ECM components can also serve as an… Expand
Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease.
Acute graft-versus-host disease (aGVHD) is the leading cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Approximately 35% to 50% of HCT recipients develop… Expand
Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes.
T cell receptor (TCR) alpha alleles undergo primary and secondary rearrangement in double-positive (DP) thymocytes. By analyzing TCRalpha rearrangement in orphan nuclear receptor RORgamma-deficient… Expand
Progressive Aortic Dilation Is Regulated by miR-17-Associated miRNAs.
- J. Wu, Hui-fang Song, +10 authors Ren-Ke Li
- Journal of the American College of Cardiology
- 28 June 2016
BACKGROUND Patients with a bicuspid aortic valve (BAV) are at increased risk for progressive aortic dilation associated with extracellular matrix (ECM) degradation by matrix metalloproteinases (MMP).… Expand
Regulation of the TCRα repertoire by the survival window of CD4+CD8+ thymocytes
T cell receptor (TCR) α alleles undergo primary and secondary rearrangement in double-positive (DP) thymocytes. By analyzing TCRα rearrangement in orphan nuclear receptor RORγ-deficient mice, in… Expand
Genetic Modification of Mesenchymal Stem Cells Overexpressing CCR1 Increases Cell Viability, Migration, Engraftment, and Capillary Density in the Injured Myocardium
Rationale: Although mesenchymal stem cell (MSC) transplantation has been shown to promote cardiac repair in acute myocardial injury in vivo, its overall restorative capacity appears to be restricted… Expand
An essential function for the calcium-promoted Ras inactivator in Fcγ receptor–mediated phagocytosis
Fc receptor (FcR)–mediated phagocytosis requires activation of the Rho GTPases Cdc42 and Rac1, but how they are recruited to the FcR is unknown. Here we show that the calcium-promoted Ras inactivator… Expand
Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a.
- Z. Zhang, Arjun Deb, +5 authors V. Dzau
- Biology, Medicine
- Journal of molecular and cellular cardiology
- 31 October 2007
We have demonstrated that mesenchymal stem cells overexpressing the survival gene Akt can confer paracrine protection to ischemic myocytes both in vivo and in vitro through the release of secreted… Expand
Tools to Support Policy Decisions Related to Treatment Strategies and Surveillance of Schistosomiasis Japonica towards Elimination
Background Appropriate diagnostics to monitor disease trends and assess the effectiveness and impact of interventions are essential for guiding treatment strategies at different thresholds of… Expand