Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library.
- C. Carroll, H. Patel, R. Dolle
- Biology, ChemistryBioorganic & Medicinal Chemistry Letters
- 8 September 1998
A statistical-based approach to assessing the fidelity of combinatorial libraries encoded with electrophoric molecular tags. Development and application of tag decode-assisted single bead LC/MS…
- R. Dolle, J. Guo, C. Carroll
- Computer ScienceJournal of combinatorial chemistry
- 21 October 2000
A statistical sampling protocol is described to assess the fidelity of libraries encoded with molecular tags and the physical existence of library compounds eluted from beads is established by comparing the molecular weight predicted by tag decode with empirical measurement.
Synthesis and pharmacological evaluation of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methylguanidines as N-methyl-D-aspartate receptor ion-channel blockers.
- L. Hu, J. Guo, S. Magar, J. Fischer, K. Burke-Howie, G. J. Durant
- Chemistry, BiologyJournal of Medicinal Chemistry
- 19 December 1997
A series of substituted diphenylguanidines 6 which are structurally related to N-1-naphthyl-N'-(3-ethylphenyl)-N'-methylguanidine found that the binding affinity of guanidine of type 6 could be further enhanced with the appropriate substitution at R3, and the structure--activity relationships for these compounds at the NMDA receptor ion-channel site are discussed.
Design, synthesis, and pharmacological evaluation of conformationally constrained analogues of N,N'-diaryl- and N-aryl-N-aralkylguanidines as potent inhibitors of neuronal Na+ channels.
- M. Maillard, M. Perlman, G. J. Durant
- Chemistry, BiologyJournal of Medicinal Chemistry
- 3 July 1998
The retention of significant neuronal Na+ blockade in all types of semirigid conformers gives evidence for a multiple mode of binding in this class of compounds and can possibly be attributed to a poor structural specificity of the site(s) of action.
Solution-phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers.
- S. Padmanabhan, R. C. Lavin, R. McBurney
- Chemistry, BiologyBioorganic & Medicinal Chemistry Letters
- 17 December 2001