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Phosphate‐Dependent Regulation of MGP in Osteoblasts: Role of ERK1/2 and Fra‐1
Data show, for the first time, that Pi regulates MGP expression in osteoblasts through the ERK1/2‐Fra‐1 pathway and that Fra‐1 interacts with the MGP promoter in response to Pi in MC3T3‐E1 cells.
Differential effects of hypoxia on osteochondrogenic potential of human adipose-derived stem cells.
The results highlight the differential regulatory role of hypoxia on the chondrogenic and osteogenic differentiation processes of hATSC and could help to exploit the potential of tissue engineering and stem cells to replace or restore the function of osteoarticular tissues.
Local delivery of bisphosphonate from coated orthopedic implants increases implants mechanical stability in osteoporotic rats.
It is shown that orthopedic implants containing bisphosphonates could be beneficial for osteoporotic patients in need of a total joint replacement.
Mesenchymal stem cell therapy to rebuild cartilage.
Human osteosarcoma cells express functional receptor activator of nuclear factor‐kappa B
This study is the first report of functional RANK expression in human osteosarcoma cells, which strengthens the involvement of the RANK–RANKL–OPG axis in primary bone tumour biology and identifies novel therapeutic approaches targeting RANK‐positive osteosARcoma.