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Cartilage engineering: a crucial combination of cells, biomaterials and biofactors.
Injuries to articular cartilage are one of the most challenging issues of musculoskeletal medicine due to the poor intrinsic ability of this tissue for repair. The lack of efficient modalities ofExpand
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Oxidative stress in bone remodelling and disease.
Oxidative stress is characterised by an increased level of reactive oxygen species (ROS) that disrupts the intracellular reduction-oxidation (redox) balance. Although initially shown to be involvedExpand
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From osteoarthritis treatments to future regenerative therapies for cartilage.
Osteoarthritis (OA) is associated with cartilage degeneration and an accompanying inflammatory syndrome of the synovium in addition to alteration of the subchondral bone. The molecular and cellularExpand
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Phosphate‐Dependent Regulation of MGP in Osteoblasts: Role of ERK1/2 and Fra‐1
Inorganic phosphate (Pi) and the matrix Gla protein (MGP) are key regulators of bone formation. We have recently shown that Pi upregulates MGP in growth plate chondrocytes, which may represent aExpand
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Phosphate-dependent stimulation of MGP and OPN expression in osteoblasts via the ERK1/2 pathway is modulated by calcium.
Inorganic phosphate (Pi) acts as a signaling molecule in bone-forming cells, affecting cell functions and gene expression. Particularly, Pi stimulates the expression of mineralization-associatedExpand
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The lumbar intervertebral disc: from embryonic development to degeneration.
Lumbar intervertebral discs (IVDs) are prone to degeneration upon skeletal maturity. In fact, this process could explain approximately 40% of the cases of low back pain in humans. Despite theExpand
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Local delivery of bisphosphonate from coated orthopedic implants increases implants mechanical stability in osteoporotic rats.
Patients with osteoporosis and joint disabilities represent a constant growing and challenging population to be treated in the musculoskeletal clinical field. Especially in the case of total hipExpand
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Differential effects of hypoxia on osteochondrogenic potential of human adipose-derived stem cells.
Human adipose tissue-derived stem cells (hATSC) have been contemplated as reparative cells for cartilage engineering. Chondrogenic differentiation of hATSC can be induced by an enriched cultureExpand
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Mesenchymal stem cell therapy to rebuild cartilage.
Disorders affecting cartilage touch almost the whole population and are one of the leading causes of invalidity in adults. To repair cartilage, therapeutic approaches initially focused on theExpand
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Phosphate Is a Specific Signal for ATDC5 Chondrocyte Maturation and Apoptosis‐Associated Mineralization: Possible Implication of Apoptosis in the Regulation of Endochondral Ossification
Involvement of Pi and Ca in chondrocyte maturation was studied because their levels increase in cartilage growth plate. In vitro results showed that Pi increases type X collagen expression, andExpand
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