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Time outdoors and physical activity as predictors of incident myopia in childhood: a prospective cohort study.
TLDR
Time spent outdoors was predictive of incident myopia independently of physical activity level, and the greater association observed for time outdoors suggests that the previously reported link between "sports/outdoor activity" and incidentMyopia is due mainly to its capture of information relating to time outdoors rather than physical activity.
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Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia
TLDR
The CREAM consortium conducted genome-wide meta-analyses, which identified 16 new loci for refractive error in individuals of European ancestry and 8 were shared with Asians, and identified 8 additional associated loci.
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Genetic association of insulin-like growth factor-1 polymorphisms with high-grade myopia in an international family cohort.
TLDR
A genetic association between IGF-1 and high-grade myopia is supported, in line with recent evidence in an experimental myopia model showing that IGF- 1 promotes ocular growth and axial myopia.
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Form-deprivation myopia induces activation of scleral matrix metalloproteinase-2 in tree shrew.
TLDR
It is demonstrated that form-deprivation myopia and recovery from myopia alter scleral catabolism and provide further support for the theory that changes in eye size during mammalian refractive development are the result of active tissue remodeling rather than passive sCleral stretching alone.
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Measurement of intraocular pressure (IOP) in chickens using a rebound tonometer: quantitative evaluation of variance due to position inaccuracies.
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Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia
TLDR
The CREAM consortium conducted genome-wide meta-analyses, which identified 16 new loci for refractive error in individuals of European ancestry and 8 were shared with Asians, and identified 8 additional associated loci.
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COL1A1 and COL2A1 genes and myopia susceptibility: evidence of association and suggestive linkage to the COL2A1 locus.
TLDR
The COL2A1 gene was associated with high-grade myopia in two independent Caucasian family datasets, indicating possible heterogeneity across different ethnicities and COL1A2 gene polymorphisms were not associated with myopia.
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Season of birth, daylight hours at birth, and high myopia.
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IMI – Interventions for Controlling Myopia Onset and Progression Report
TLDR
There are multiple avenues for intervention worthy of exploration in all categories, although in the case of optical, pharmacological, and behavioral interventions for preventing or slowing progression of myopia, treatment efficacy at an individual level appears quite variable.
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Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
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