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Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis.
TLDR
More patients with hepatocellular carcinoma could be candidates for transplantation if the current dual approach to candidacy, based on the strict Milan criteria, were replaced with a more precise estimation of survival contouring individual tumour characteristics and use of the up-to-seven criteria. Expand
Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH.
TLDR
Hencidin is a proinflammatory adipokine and may play an important role in hypoferremia of inflammation in obese condition and be a negative regulator of intestinal iron absorption and macrophage iron efflux. Expand
Liver transplantation for hepatocellular carcinoma: a model including α-fetoprotein improves the performance of Milan criteria.
BACKGROUND & AIMS The aim of this study was to generate an improved prognostic model for predicting recurrence in liver transplant candidates with hepatocellular carcinoma (HCC). METHODS PredictorsExpand
Identification of Adipose Tissue Dendritic Cells Correlated With Obesity-Associated Insulin-Resistance and Inducing Th17 Responses in Mice and Patients
TLDR
These DCs were functional and could be important regulators of adipose tissue inflammation by regulating the switch toward Th17 cell responses in obesity-associated insulin resistance. Expand
Hepatic Expression Patterns of Inflammatory and Immune Response Genes Associated with Obesity and NASH in Morbidly Obese Patients
TLDR
The liver of obese patients without histological abnormalities already displayed a low-grade inflammation and could be more responsive to activators of the TLR pathway, which helps to identify new potential actors of the pathogenesis of NAFLD. Expand
Laparoscopic splenectomy: outcome and efficacy in 103 consecutive patients.
TLDR
LS should become the technique of choice for treatment of intractable benign hematologic disease and Rigorous technique will minimize capsular fractures, reducing the risk of splenosis. Expand
Liver transplantation across ABO blood group barriers
TLDR
The use of ABO-incompatible liver grafts is justifiable in emergencies, when no other donor is available; such transplants may help to save the patient, even at the cost of retransplantation in half of the cases. Expand
ER stress induces NLRP3 inflammasome activation and hepatocyte death
TLDR
It is demonstrated here that ER stress leads to hepatic NLRP3 inflammasome pyroptotic death, thus contributing as a novel mechanism of inflammation-mediated liver injury in chronic liver diseases. Expand
The Inflammatory C-Reactive Protein is Increased in Both Liver and Adipose Tissue in Severely Obese Patients Independently from Metabolic Syndrome, Type 2 Diabetes, and NASH
TLDR
Plasma CRP levels are not predictive of the diagnosis of NASH in severely obese patients, and the liver but also the adipose tissue can produce CRP, a process which could be dependent on IL6, therefore, both tissues might contribute to the elevated plasmaCRP levels found in obesity. Expand
Impact of pretransplantation transarterial chemoembolization on survival and recurrence after liver transplantation for hepatocellular carcinoma
TLDR
In conclusion, with a mean waiting period of 4.2 months and 1 TACE procedure, pre‐LT TACE does not influence post‐LT overall survival and disease‐free survival. Expand
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