Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic…
- J. Fawcett, A. Curt, D. Short
- Medicine, BiologySpinal Cord
- 30 March 2007
The spontaneous rate of recovery after SCI and resulting consequences for achieving statistically significant results in clinical trials are examined, based on previous data of the magnitude of spontaneous recovery afterSCI, as measured by changes in ASIA motor scores.
Demyelination and Schwann cell responses adjacent to injury epicenter cavities following chronic human spinal cord injury
- J. Guest, E. D. Hiester, R. Bunge
- BiologyExperimental Neurology
- 1 April 2005
The Ability of Human Schwann Cell Grafts to Promote Regeneration in the Transected Nude Rat Spinal Cord
- J. Guest, Arundathi Rao, L. Olson, M. Bunge, R. Bunge
- Biology, MedicineExperimental Neurology
- 1 December 1997
This study showed that in the nude rat given methylprednisolone in combination with human SC grafts, some regenerative growth occurred beyond the graft and a modest improvement in function was observed.
Traumatic central cord syndrome: results of surgical management.
- J. Guest, M. Eleraky, P. Apostolides, C. Dickman, V. Sonntag
- MedicineJournal of Neurosurgery
- 1 July 2002
Early surgery is safe and more cost effective than late surgery for the treatment of traumatic CCS, based on ICU stay and LOS and improved overall motor recovery, in patients whose CCS was related to acute disc herniation or fracture.
Guidelines for the conduct of clinical trials for spinal cord injury (SCI) as developed by the ICCP panel: clinical trial outcome measures
- J. Steeves, D. Lammertse, A. Privat
- Psychology, MedicineSpinal Cord
- 30 March 2007
An international panel reviewed the methodology for clinical trials of spinal cord injury (SCI), and provided recommendations for the valid conduct of future trials, and focused on outcome measures that are relevant toclinical trials of experimental cell-based and pharmaceutical drug treatments.
Safety of Autologous Human Schwann Cell Transplantation in Subacute Thoracic Spinal Cord Injury.
- K. Anderson, J. Guest, A. Levi
- Medicine, BiologyJournal of Neurotrauma
- 1 November 2017
It is concluded that it is feasible to identify eligible candidates, appropriately obtain informed consent, perform a peripheral nerve harvest to obtainSCs within 5-30 days of injury, and perform an intra-spinal transplantation of highly purified autologous SCs within 4-7 weeks of injury.
Influence of IN‐1 antibody and acidic FGF‐fibrin glue on the response of injured corticospinal tract axons to human Schwann cell grafts
- J. Guest, D. Hesse, L. Schnell, M. Schwab, M. Bunge, R. Bunge
- BiologyJournal of Neuroscience Research
- 1 December 1997
Human SC grafts alone do not support the regeneration of injured CST fibers and do not prevent die‐back, but grafts plus IN‐1 antibody‐containing supernatant support some sprouting but die‐ back continues, and graftsplus aFGF‐fibrin glue support regeneration of some fibers into the grafts and reduce die‐backs.
International Standards for Neurological Classification of Spinal Cord Injury: Revised 2019.
- R. Rupp, F. Biering-Sørensen, S. Kirshblum
- MedicineTopics in Spinal Cord Injury Rehabilitation
- 2021
This booklet contains the eighth edition of the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) that describes the examination as well as the classification including the American Spinal Injury Association (ASIA) Impairment Scale (AIS).
Cellular Transplants in China: Observational Study from the Largest Human Experiment in Chronic Spinal Cord Injury
Perioperative morbidity and lack of functional benefit were identified as the most serious clinical shortcomings and physicians should not recommend this procedure to patients.
Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP Panel: clinical trial inclusion/exclusion criteria and ethics
- M. Tuszynski, J. Steeves, A. Privat
- MedicineSpinal Cord
- 30 March 2007
Examination of inclusion and exclusion criteria that can influence the design and analysis of clinical trials in SCI, together with confounding variables and ethical considerations are examined.
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