• Publications
  • Influence
Tryptophan Depletion During Continuous CSF Sampling in Healthy Human Subjects
The tryptophan (TRP) depletion paradigm has been employed to investigate mood and behavioral effects of acutely lowering plasma TRP, and presumably brain serotonin (5-hydroxytryptamine [5-HT]) levelsExpand
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Opioid Related Endocrinopathy.
OBJECTIVE Millions of patients continue to require opioid analgesics for control of moderate to severe chronic pain, which is a disease that affects more Americans than cancer, heart disease, andExpand
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Opioid therapies and cytochrome p450 interactions.
  • J. Gudin
  • Medicine
  • Journal of pain and symptom management
  • 1 December 2012
Adverse drug reactions are common and associated with substantial economic and human costs. Particularly among older adult populations, preventable adverse drug reactions are often caused byExpand
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Levorphanol use: past, present and future
Abstract Levorphanol is a potent opioid analgesic that was first approved for use in the United States in 1953. Levorphanol is approved for use in moderate to severe pain where an opioid analgesic isExpand
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Central nervous system abnormalities in complex regional pain syndrome (CRPS): clinical and quantitative evidence of medullary dysfunction.
OBJECTIVE Sensory and motor abnormalities are common among patients with complex regional pain syndrome (CRPS). The purpose of the present study was to define and characterize these abnormalities andExpand
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Rational Urine Drug Monitoring in Patients Receiving Opioids for Chronic Pain: Consensus Recommendations
Abstract Objective To develop consensus recommendations on urine drug monitoring (UDM) in patients with chronic pain who are prescribed opioids. Methods An interdisciplinary group of clinicians withExpand
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Opioid abuse-deterrent strategies: role of clinicians in acute pain management
Abstract Opioid abuse is a healthcare and societal problem that burdens individuals, their families and the healthcare professionals who care for them. Restricting access to opioid analgesics is oneExpand
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Clinical Strategies for the Primary Health Care Professional to Minimize Prescription Opioid Abuse
  • J. Gudin
  • Medicine
  • Postgraduate medicine
  • 1 May 2012
Abstract Prescription opioid analgesic therapy can be effective in managing chronic noncancer pain in appropriately selected patients. However, the risks and benefits of prescription opioids shouldExpand
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ICU pneumonias: a multi-institutional study.
We conducted a prospective multi-institutional study of nosocomial and community-acquired pneumonias in 1378 patients admitted to the ICUs of six hospitals. We also investigated 1005 of theseExpand
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