Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1
Two SNPs, rs1051730 and rs8034191, mapping to a region of strong linkage disequilibrium within 15q25.1 containing PSMA4 and the nicotinic acetylcholine receptor subunit genes CHRNA3 and CHRNA5, were significantly associated with risk in both replication sets.
Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer
A missense variant (rs2294008) in the PSCA gene showed consistent association with bladder cancer in US and European populations and was identified as a new bladder cancer susceptibility locus.
An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin.
A novel HER3 monoclonal antibody that can neutralize multiple modes of HER3 activation is described, making it a superior candidate for clinical translation as a therapeutic candidate and establishing that LJM716 possesses a novel mechanism of action that, in combination with HER2- or EGFR-targeted agents, may leverage their clinical efficacy in ErbB-driven cancers.
Genetic Variations in MicroRNA-Related Genes Are Novel Susceptibility Loci for Esophageal Cancer Risk
The present study provides the first evidence that miRNAs may affect esophageal cancer risk in general and that specific genetic variants in miRNA-related genes may affect the risk individually and jointly.
MicroRNAs and their isomiRs function cooperatively to target common biological pathways
IsomiRs are found to be biologically relevant and functionally cooperative partners of canonical miRNAs that act coordinately to target pathways of functionally related genes and helps explain a major miRNA paradox.
Single Nucleotide Polymorphisms of microRNA Machinery Genes Modify the Risk of Renal Cell Carcinoma
The results suggested that genetic polymorphisms of the miRNA-machinery genes may affect renal cell carcinoma susceptibility individually and jointly.
Nucleotide Excision Repair Gene Polymorphisms and Recurrence after Treatment for Superficial Bladder Cancer
The data suggest that interindividual differences in DNA repair capacity may have an important impact on superficial bladder cancer recurrence, and a pathway-based approach is preferred to study the effects of individual polymorphism on clinical outcomes.
Polymorphisms in inflammation genes and bladder cancer: from initiation to recurrence, progression, and survival.
Inflammation gene polymorphisms are associated with modified BC risk, treatment response, and survival and were associated with improved 5-year overall and disease-specific survival in patients with invasive BC and non-muscle-invasive BC.
MicroRNA Expression Signatures in Barrett's Esophagus and Esophageal Adenocarcinoma
It is shown that miRNA expression profiles in tissues of Barrett's esophagus with high-grade dysplasia were significantly different from their corresponding normal tissues, and several miRNAs were involved in the development and progression of esophageal adenocarcinoma.
Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes.
The data suggest that individuals with a higher number of genetic variations in DNA-repair and cell-cycle-control genes are at an increased risk for bladder cancer, confirming the importance of taking a multigenic pathway-based approach to risk assessment.