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Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity
STAT6 mediates immune signaling in response to both cytokines at the plasma membrane, and virus infection at the endoplasmic reticulum, and Stat6(-/-) mice are susceptible to virus infection. Expand
Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway
The identification of somatic mutations for GBC in 57 tumor-normal pairs through a combination of exome sequencing and ultra-deep sequencing of cancer-related genes provides insight into the somatic mutational landscape and highlights the key role of the ErbB signaling pathway in GBC pathogenesis. Expand
Klotho suppresses RIG-I-mediated senescence-associated inflammation
It is well known that aged or senescent cells develop a complex senescence-associated secretory phenotype (SASP), which is observed both in culture and in vivo. However, the mechanisms underlying the… Expand
Neuroprotection by baicalein in ischemic brain injury involves PTEN/AKT pathway
J. Neurochem. (2010) 112, 1500–1512.
Paeoniflorin Protects against Ischemia-Induced Brain Damages in Rats via Inhibiting MAPKs/NF-κB-Mediated Inflammatory Responses
It is shown that PF treatment for 14 days could significantly inhibit transient middle cerebral artery occlusion (MCAO)-induced over-activation of astrocytes and microglia, and prevented up-regulations of pro-inflamamtory mediators in plasma and brain. Expand
Genetic polymorphisms of the human CYP2A13 gene: identification of single-nucleotide polymorphisms and functional characterization of an Arg257Cys variant.
- Xiuling Zhang, T. Su, +4 authors X. Ding
- Biology, Medicine
- The Journal of pharmacology and experimental…
- 1 August 2002
The Arg257Cys mutation could provide some protection against xenobiotic toxicity in the respiratory tract to individuals who are homozygous for the Cys-257 allele. Expand
Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-kappaB pathways and inhibition of intracellular ROS/RNS generation.
- Ting Wang, J. Gu, +6 authors Jian-Guo Chen
- Biology, Medicine
- Free radical biology & medicine
- 1 August 2009
This study indicates that 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside protects against cerebral ischemia/reperfusion injury through multifunctional cytoprotective pathways. Expand
The challenges of mainstream deammonification process for municipal used water treatment
- G. Xu, Yan Zhou, +5 authors Yu Liu
- Chemistry, Medicine
- Applied Microbiology and Biotechnology
- 1 February 2015
This paper attempts to provide a detailed analysis of three main challenges of the mainstream deammonification process for municipal used water treatment, including high COD/N ratio leading to denitrifiers outcompeting Anammox bacteria, and numerous difficulties in selective retention of ammonia-oxidizing bacteria. Expand
NuRD Blocks Reprogramming of Mouse Somatic Cells into Pluripotent Stem Cells
It is shown that downregulation of the nucleosome remodeling and deacetylation (NuRD) complex is required for efficient reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) and establishes Mbd3/NURD as an important epigenetic regulator that restricts the expression of key pluripotency genes. Expand
Marinobacter gudaonensis sp. nov., isolated from an oil-polluted saline soil in a Chinese oilfield.
- J. Gu, H. Cai, +5 authors Xiao-Lei Wu
- Biology, Medicine
- International journal of systematic and…
- 1 February 2007
Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain SL014B61A(T) belonged to the genus Marinobacter in the class Gammaproteobacteria, which is proposed to represent a novel species, Marinobacteria gudaonensis sp. Expand