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THE TWO-PERIOD CHANGE-OVER DESIGN AN ITS USE IN CLINICAL TRIALS.
  • J. Grizzle
  • Mathematics, Medicine
  • Biometrics
  • 1 June 1965
TLDR
This comparison shows that the two-period changeover design is preferable when the residual effects of the treatments are equal and the correlation between the response to the two tieatments is positive, otherwise the design in which there is random assignment to a single treatment is preferable. Expand
Analysis of categorical data by linear models.
TLDR
The special cases of linear functions and logarithmic functions of the 7rin are developed in detail, and some examples of how the general approach can be used to analyze various types of categorical data are presented. Expand
Analysis of growth and dose response curves.
TLDR
The method yields results identical to those obtained by weighting inversely by the sample covariance matrix, but has the additional feature of allowing flexibility in weighting by choosing subsets of covariates that have special properties. Expand
Analysis of data from multiclinic trials.
A Split Questionnaire Survey Design
TLDR
A multiple imputation method for analyzing data from this design is developed, in which the imputations are created by random draws from the posterior predictive distribution of the missing parts, given the observed parts by using Gibbs sampling under a general location scale model. Expand
The Women's Health Trial Feasibility Study in Minority Populations: changes in dietary intakes.
TLDR
The reported reduction in fat intake was similar to the approximately 10% of energy decrease found in most trials and suggests that large changes in fat consumption can be attained in diverse study populations and in many subgroups. Expand
Cancer control at the workplace: the Working Well Trial.
TLDR
An overview of the largest worksite cancer control trial in the United States--The Working Well Trial--conducted in 114 worksites by four study centers, a coordinating center, and the National Cancer Institute is presented. Expand
Estimation of Time-Response Curves and Their Confidence Bands
The study of a biological process over a period of time is often of interest in physiological and medical investigations. Important examples of this are afforded by curves describing secretion andExpand
Nutritional and environmental factors involved in egg shell quality of laying hens.
TLDR
It is suggested that midnight lighting programmes provide a means of supporting egg shell quality of older laying hens during the summer months without a significant reduction in egg production. Expand
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