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Proposed minimum reporting standards for chemical analysis
We propose the minimum reporting standards related to the chemical analysis aspects of metabolomics experiments including: sample preparation, experimental analysis, quality control, metabolite identification, and data pre-processing. Expand
Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress
The etiology and pathophysiology of schizophrenia remain unknown. A parallel transcriptomics, proteomics and metabolomics approach was employed on human brain tissue to explore the molecular disease… Expand
MetaboLights—an open-access general-purpose repository for metabolomics studies and associated meta-data
MetaboLights (http://www.ebi.ac.uk/metabolights) is the first general-purpose, open-access repository for metabolomics studies, their raw experimental data and associated metadata, maintained by one of the major open- access data providers in molecular biology. Expand
Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes.
Ketosis, the metabolic response to energy crisis, is a mechanism to sustain life by altering oxidative fuel selection. Often overlooked for its metabolic potential, ketosis is poorly understood… Expand
Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy.
- W. Dunn, D. Broadhurst, H. Atherton, R. Goodacre, J. Griffin
- Chemistry, Medicine
- Chemical Society reviews
The study of biological systems in a holistic manner (systems biology) is increasingly being viewed as a necessity to provide qualitative and quantitative descriptions of the emergent properties of… Expand
Mapping the Arabidopsis organelle proteome.
- T. Dunkley, S. Hester, +10 authors K. Lilley
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 25 April 2006
A challenging task in the study of the secretory pathway is the identification and localization of new proteins to increase our understanding of the functions of different organelles. Previous… Expand
Metabolic profiles of cancer cells
In the post-genomic era, several profiling tools have been developed to provide a more comprehensive picture of tumour development and progression. The global analysis of metabolites, such as by mass… Expand
A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human.
Type 2 diabetes mellitus is the result of a combination of impaired insulin secretion with reduced insulin sensitivity of target tissues. There are an estimated 150 million affected individuals… Expand
Localization of Organelle Proteins by Isotope Tagging (LOPIT)*S
- T. Dunkley, R. Watson, J. Griffin, P. Dupree, K. Lilley
- Biology, Medicine
- Molecular & Cellular Proteomics
- 1 November 2004
We describe a proteomics method for determining the subcellular localization of membrane proteins. Organelles are partially separated using centrifugation through self-generating density gradients.… Expand
A metabolomics based approach to assessing the toxicity of the polyaromatic hydrocarbon pyrene to the earthworm Lumbricus rubellus.
The biochemical response of the earthworm Lumbricus rubellus to pyrene exposure was assessed using 1H nuclear magnetic resonance (NMR) spectroscopy, gas chromatography mass spectrometry (GC-MS) and… Expand