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Proposed minimum reporting standards for chemical analysis
This article proposes the minimum reporting standards related to the chemical analysis aspects of metabolomics experiments including: sample preparation, experimental analysis, quality control, metabolite identification, and data pre-processing.
Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress
It is proposed that oxidative stress and the ensuing cellular adaptations are linked to the schizophrenia disease process and it is hoped that this new disease concept may advance the approach to treatment, diagnosis and disease prevention of schizophrenia and related syndromes.
Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes.
Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy.
- W. Dunn, D. Broadhurst, H. Atherton, R. Goodacre, J. Griffin
- Biology, ChemistryChemical Society reviews
An introduction to metabolites, metabolomes, metabolomics and the role of MS and NMR spectroscopy will be provided and the applications of metabolomics in mammalian systems biology for the study of the health-disease continuum, drug efficacy and toxicity and dietary effects on mammalian health will be reviewed.
MetaboLights—an open-access general-purpose repository for metabolomics studies and associated meta-data
The MetaboLights repository, powered by the open source ISA framework, is cross-species and cross-technique and will cover metabolite structures and their reference spectra as well as their biological roles, locations, concentrations and raw data from metabolic experiments.
Mapping the Arabidopsis organelle proteome.
- T. Dunkley, Svenja Hester, K. Lilley
- BiologyProceedings of the National Academy of Sciences…
- 25 April 2006
The localization of organelle proteins by the isotope tagging technique in conjunction with isotope tags for relative and absolute quantitation and 2D liquid chromatography for the simultaneous assignment of proteins to multiple subcellular compartments has enabled protein steady-state distributions to be determined.
A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human.
Type 2 diabetes mellitus is the result of a combination of impaired insulin secretion with reduced insulin sensitivity of target tissues. There are an estimated 150 million affected individuals…
Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells.
- S. T. Rashid, S. Corbineau, L. Vallier
- Biology, MedicineThe Journal of clinical investigation
- 1 September 2010
These patient-derived hepatocytes demonstrate that it is possible to model diseases whose phenotypes are caused by pathological dysregulation of key processes within adult cells, and a simple and effective platform for hepatocyte generation from patient-specific human iPS cells.
Metabolic profiles of cancer cells
Global analysis of metabolites, such as by mass spectrometry and high-resolution 1H nuclear magnetic resonance spectroscopy, can be used to define the metabolic phenotype of cells, tissues or organisms.
Localization of Organelle Proteins by Isotope Tagging (LOPIT)*S
- T. Dunkley, R. Watson, J. Griffin, P. Dupree, K. Lilley
- BiologyMolecular & Cellular Proteomics
- 1 November 2004
A proteomics method for determining the subcellular localization of membrane proteins in both the endoplasmic reticulum and the Golgi apparatus in Arabidopsis using a new tool for high-throughput protein localization by isotope tagging.