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Effect of endothelin-1 on alpha-smooth muscle actin expression and on alveolar fibroblasts proliferation in interstitial lung diseases.
Endothelin-1 (ET-1) is a potent constrictor and mitogen peptide which is expressed in several pulmonary diseases. To elucidate the involvement of ET-1 in lung interstitial pathologic events, we… Expand
Pulmonary alveolar proteinosis in Israel: ethnic clustering.
- I. Ben-Dov, Y. Kishinevski, +8 authors D. Weiler-Ravel
- The Israel Medical Association journal : IMAJ
- 1 October 1999
BACKGROUND Pulmonary alveolar proteinosis is a rare disease in which a surfactant-like phospholipid-rich protein accumulates in the lungs. The disease is amenable to effective therapy by total lung… Expand
Effect of IL-6 on alveolar fibroblast proliferation in interstitial lung diseases.
- I. Shahar, E. Fireman, +4 authors S. Ben Efraim
- Clinical immunology and immunopathology
- 1 June 1996
Alveolar macrophage-fibroblast interaction may be involved in the pathogenesis of interstitial lung diseases (ILD). Herein, we compared IL-6 secretion from alveolar macrophages (AM) and alveolar… Expand
Mitochondrial free radical generation and lifespan control in the fungal aging model Podospora anserina
In the filamentous fungus Podospora anserina a central role of mitochondria in the control of aging has been repeatedly demonstrated. Interestingly, impairments in cytochrome c oxidase (COX) activity… Expand
Mode of translational activation of the catalase (cat1) mRNA of rye leaves (Secale cereale L.) and its control through blue light and reactive oxygen
The enzyme catalase (EC 22.214.171.124) is inactivated by light and must be continuously replaced by new synthesis in order to maintain a constant enzyme activity in leaves. In winter rye leaves (Secale… Expand
Cholesterol crystals in BAL fluid from patients with idiopathic pulmonary fibrosis.
Abnormalities in pulmonary surfactant phospholipids from patients with idiopathic pulmonary fibrosis (IPF) correlate with the nature of the histopathological and clinical impairment (1). This report… Expand
Morphological and Biochemical Properties of Alveolar Fibroblasts in Interstitial Lung Diseases
- E. Fireman, I. Shahar, S. Shoval, G. Messer, S. Dvash, J. Grief
- Chemistry, Medicine
- 6 December 2001
The phenotype of alveolar-associated fibroblasts (Afb) in sarcoidosis (SA) and idiopathic pulmonary fibrosis (IPF) is unclear. In the present study, we characterized the cytoskeletal proteins and the… Expand
Age-Related Cellular Copper Dynamics in the Fungal Ageing Model Podospora anserina and in Ageing Human Fibroblasts
In previous investigations an impact of cellular copper homeostasis on ageing of the ascomycete Podospora anserina has been demonstrated. Here we provide new data indicating that mitochondria play a… Expand
High extracellular induced sputum haem oxygenase‐1 in sarcoidosis and chronic beryllium disease
- N. Kokturk, M. Sabag, M. Stark, J. Grief, E. Fireman
- European journal of clinical investigation
- 1 July 2009
Background Sarcoidosis and chronic beryllium disease (CBD) are inflammatory conditions in which oxidative stress state may be crucial for disease outcome. This study compares haem oxygenase‐1 (HO‐1)… Expand
Modellierung von Flexibilität mit Ereignisgesteuerten Prozessketten (EPK)
Weiterhin ergab eine Umfrage unter mehr als 4000 Führungskräften weltweit, dass die Fähigkeit, Flexibilität tatsächlich auch in Unternehmenswandel umzusetzen, als größte Managementherausforderung bis 2010 betrachtet wird. Expand