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Gene Targeting Reveals a Critical Role for Neurturin in the Development and Maintenance of Enteric, Sensory, and Parasympathetic Neurons
The loss of GFR alpha2-expressing neurons, in conjunction with earlier studies, provides strong support for GFRalpha2/Ret receptor complexes as the critical mediators of NTN function in vivo. Expand
GDNF availability determines enteric neuron number by controlling precursor proliferation
These analyses demonstrate that glial cell line-derived neurotrophic factor (GDNF) and neurturin are important for different aspects of ENS development, and that Ret signaling is critical for both ENS structure and function. Expand
Inhibition of sustained smooth muscle contraction by PKA and PKG preferentially mediated by phosphorylation of RhoA.
Results demonstrate that dephosphorylation of MLC(20) and smooth muscle relaxation are preferentially mediated by PKG- and PKA-dependent phosphorylation and inactivation of RhoA. Expand
Enteric motor and interneuronal circuits controlling motility
This review summarizes the knowledge of motor neurones and interneurones in simple motility reflex pathways (ascending and descending excitation, descending inhibition) and it focuses on guinea‐pig ileum. Expand
Inhibition of Monoacylglycerol Lipase Attenuates Nonsteroidal Anti-Inflammatory Drug-Induced Gastric Hemorrhages in Mice
Data indicate that increasing 2-AG protects against gastric damage induced by NSAIDs, and its primary catabolic enzyme MAGL offers a promising target for the development of analgesic therapeutics possessing gastroprotective properties. Expand
5-HT released by mucosal stimuli initiates peristalsis by activating 5-HT4/5-HT1p receptors on sensory CGRP neurons.
It is concluded that 5-HT released by mucosal stimulation initiates the peristaltic reflex by activating 5- HT4/5-HT1p receptors on sensory CGRP-containing neurons. Expand
G(i-1)/G(i-2)-dependent signaling by single-transmembrane natriuretic peptide clearance receptor.
It is concluded that NPR-C is coupled to activation of PLC-beta3 via betagamma-subunits of G(i-1) and G( i-2) and to inhibition of adenylyl cyclase via alpha-sub units and toactivation of cAMP- and cGMP-dependent protein kinases. Expand
American Journal of Physiology: Gastrointestinal and Liver Physiology American Journal of Physiology: Heart and Circulatory Physi- QlQgY American Journal of Physiology: Regulatory, Integrative and
s Invited for Fourth Annual Workshop on PULMONARY PHYSIOLOGY AND FUNCTlON TESTlNG IN SMALL LABORATORY ANI Satellite Conference to the Annual Meeting of the AMERICAN THORACIC SOCIETY
Stimulation of nitric oxide from muscle cells by VIP: prejunctional enhancement of VIP release.
No amplifies the relaxant effect of VIP in muscle cells and acts presynaptically to enhance the release of VIP, which concludes that VIP is the primary relaxant transmitter in both gastric muscle and tenia coli. Expand
Interplay of VIP and nitric oxide in regulation of the descending relaxation phase of peristalsis.
  • J. Grider
  • Chemistry, Medicine
  • The American journal of physiology
  • 1 February 1993
Involvement of vasoactive intestinal peptide and nitric oxide in neurally induced relaxation was examined in smooth muscle from rat colon and it was implied that NO production normally acts to enhance VIP release. Expand