Transcriptional Repression by Blimp-1 (PRDI-BF1) Involves Recruitment of Histone Deacetylase
- Jin Yu, C. Angelin-Duclos, J. Greenwood, J. Liao, K. Calame
- BiologyMolecular and Cellular Biology
- 1 April 2000
The results show that Blimp-1 represses the c-mycpromoter by an active mechanism that is independent of the adjacently bound activator YY1, and the functional importance of recruiting HDAC for Blimp-1-dependent repression of c- myctranscription is supported.
Non-coding telomeric and subtelomeric transcripts are differentially regulated by telomeric and heterochromatin assembly factors in fission yeast
- J. Greenwood, J. Cooper
- BiologyNucleic Acids Research
- 1 December 2011
In vivo analyses in fission yeast suggest testable models for the roles of TERRA in telomere function and detect substantial levels of C-rich telomeric RNA whose appearance is independent of the RNA-dependent RNA polymerase, suggesting that the telomeres themselves serve as promoter sites.
Taz1 enforces cell-cycle regulation of telomere synthesis.
- P. Dehé, O. Rog, Miguel Godinho Ferreira, J. Greenwood, J. Cooper
- BiologyMolecules and Cells
- 29 June 2012
From oogenesis through gastrulation: developmental regulation of apoptosis.
- J. Greenwood, J. Gautier
- BiologySeminars in Cell and Developmental Biology
- 1 April 2005
Fission yeast telosomes: non-canonical histone-containing chromatin structures dependent on shelterin and RNA
- J. Greenwood, H. Patel, T. Cech, J. Cooper
- BiologyNucleic Acids Research
- 10 July 2018
It is shown that fission yeast chromosome ends are assembled into distinct protected structures (‘telosomes’) encompassing the telomeric DNA repeats and over half a kilobase of subtelomericDNA.
RNA polymerase II dynamics and mRNA stability feedback scale mRNA in proportion to cell size
- Matthew P. Swaffer, G. Marinov, J. Skotheim
- BiologybioRxiv
- 20 September 2021
Limiting RNAPII and feedback on mRNA stability work in concert to ensure mRNA concentration homeostasis in growing cells, supporting a dynamic equilibrium model where global transcription at a given size is set by the mass-action recruitment kinetics of unengaged nucleoplasmicRNAPII, and DNA content.
Responses to DNA damage in Xenopus: cell death or cell cycle arrest.
- J. Greenwood, V. Costanzo, K. Robertson, C. Hensey, J. Gautier
- BiologyNovartis Foundation symposium
- 2001
This work has reconstituted a DNA damage cell cycle checkpoint in vitro, demonstrating that all the checkpoint signalling components are present in the embryos but are not activated under the experimental conditions used to generate DNA damage in the embryo.
XLX is an IAP family member regulated by phosphorylation during meiosis
- J. Greenwood, J. Gautier
- BiologyCell Death and Differentiation
- 1 March 2007
X, a Xenopus laevis inhibitor of apoptosis (IAP) family member, exhibits characteristics typical of an IAP, such as caspase inhibition and autoubiquitylation, but it is found that XLX is phosphorylated during meiosis by protein kinases that belong to the MAPK and MPF pathways.
Core control principles of the eukaryotic cell cycle
- Souradeep Basu, J. Greenwood, Andrew Jones, P. Nurse
- BiologyNature
- 27 October 2021
The two opposing views of cell cycle control are reconciled, showing that the core cell cycle engine is largely based on a quantitative increase in CDK activity through the cell cycle, combined with minor and surmountable qualitative differences in catalytic specialization of S- CDKs and M-CDKs.
Genome-wide screen for cell growth regulators in fission yeast
- L. Weston, J. Greenwood, P. Nurse
- BiologyJournal of Cell Science
- 15 June 2017
Using a novel system to identify cell growth regulators, a number of factors are discovered that activate growth in cells in which growth is developmentally switched off, indicating that global transcriptional control mediated through S6 kinase signalling is central to cellular growth control.
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