J. Greenblatt

Publications297
h-index98
Citations39,794
Highly Influential Citations2,732
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • A. Emili
  • 344 Publications • 32,697 Citations
  • N. Krogan
  • 501 Publications • 52,692 Citations
  • D. Reinberg
  • 393 Publications • 70,201 Citations
  • R. Roeder
  • 708 Publications • 87,937 Citations
  • Publications
  • Influence
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae
TLDR
T tandem affinity purification was used to process 4,562 different tagged proteins of the yeast Saccharomyces cerevisiae to identify protein–protein interactions, which will help future studies on individual proteins as well as functional genomics and systems biology.
View on Nature
Global Mapping of the Yeast Genetic Interaction Network
TLDR
Because digenic interactions are common in yeast, similar networks may underlie the complex genetics associated with inherited phenotypes in other organisms.
View on Publisher
Toward a Comprehensive Atlas of the Physical Interactome of Saccharomyces cerevisiae*S
TLDR
A novel probabilistic metric is created that takes advantage of the high density of data, including both the presence and absence of individual associations, to provide a measure of the relative confidence of each potential protein-protein interaction and organized proteins into coherent multisubunit complexes using hierarchical clustering.
View on Publisher
Interaction network containing conserved and essential protein complexes in Escherichia coli
TLDR
Insight is provided into the function of previously uncharacterized bacterial proteins and the overall topology of a microbial interaction network, the core components of which are broadly conserved across Prokaryota.
View on Springer
Cotranscriptional Set2 Methylation of Histone H3 Lysine 36 Recruits a Repressive Rpd3 Complex
View on Elsevier
A Bayesian Networks Approach for Predicting Protein-Protein Interactions from Genomic Data
TLDR
This work develops an approach using Bayesian networks to predict protein-protein interactions genome-wide in yeast, and observes that at given levels of sensitivity, the predictions are more accurate than the existing high-throughput experimental data sets.
View on Publisher
The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation.
View on PubMed
The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II
TLDR
It is shown that Rtt103 and the Rat1/Rai1 5′ → 3′ exonuclease are localized at 3′ ends of protein coding genes, supporting a model in which poly(A) site cleavage and subsequent degradation of the 3′-downstream RNA by Rat1 trigger transcription termination.
View on Nature
The C-terminal domain of RNA polymerase II couples mRNA processing to transcription
TLDR
It is shown that the carboxy-terminal domain of the pol II large subunit is required for efficient RNA processing, and an association between the CTD and 3′-processing factors suggests that an mRNA 'factory' exists which carries out coupled transcription, splicing and cleavage–polyadenylation of mRNA precursors.
View on Nature
RNA Polymerase II Elongation Factors of Saccharomyces cerevisiae: a Targeted Proteomics Approach
TLDR
To physically characterize the web of interactions connecting the Saccharomyces cerevisiae proteins suspected to be RNA polymerase II elongation factors, subunits of Spt4/Spt5 and Spt16/Pob3 were affinity purified under conditions designed to minimize loss of associated polypeptides and then identified by mass spectrometry.
View on ASMUSA
...
...