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Release of endogenous dopamine by stimulation of 5-hydroxytryptamine3 receptors in rat striatum.
Direct, unambiguous evidence is provided that in rat striatum 5-HT3 receptors modulate release of endogenous dopamine from superfused rat striatal slices. Expand
The structure, physical and chemical properties of the soy bean protein glycinin.
The major storage protein of the soybean, glycinin, has been prepared in a homogeneous form and examined by a variety of techniques and revealed three different kinds of acidic subunits and probably three kinds of basic ones also. Expand
γ-Glutamyl Transpeptidase in Brain Capillaries: Possible Site of a Blood-Brain Barrier for Amino Acids
A fraction containing capillaries and rich in γ-glutamyl transpeptidase was isolated from homogenates of bovine brain cortex by density gradient centrifugation. The enzyme was localized in theExpand
The phase behavior of monogalactosyl, digalactosyl, and sulphoquinovosyl diglycerides.
Algal sulpholipids, with much higher contents of saturated fatty acids, show a more complex behavior in that the lamellar phase formed appears to exhibit limited swelling behavior at low temperatures, whereas raising the temperature results in a gradual increase in interbilayer water uptake. Expand
Histamine metabolites in cerebrospinal fluid of patients with chronic schizophrenia: their relationships to levels of other aminergic transmitters and ratings of symptoms
The elevated levels of t-MH in cerebrospinal fluid, which represent histamine that was released and metabolized, suggest increased central histaminergic activity in patients with chronic schizophrenia. Expand
Lack of a Precursor‐Product Relationship Between Histamine and Its Metabolites in Brain After Histidine Loading
Results imply that high doses of His distort the simple precursor‐product relationship between histamine and its methylated metabolites in brain, and raise questions about the validity of using His loading as a specific probe of brain histaminergic function. Expand
Histamine as a neuroregulator.
Strong evidence now supports the view that histamine is a neuroregulator, and the enzyme that metabolizes histamine in mammalian brain, has no other known endogenous substrate. Expand
Histamine and Its Receptors in the Nervous System
Histamine was dismissed as having a role in either the pharmacological or therapeutic effects of either neuroleptic or antidepressant drugs, but these drugs do in fact interact with histamine receptors at drug concentrations that are found in plasma of patients and in brain of experimental animals. Expand
Tricyclic antidepressant drugs block histamine H2 receptor in brain
To test this hypothesis, four tricyclic antidepressants—representing four different structural types—were tested on the H2 receptor linked to adenylate cyclase in homogenates of the guinea pig hippocampus and cortex. Expand