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Enhanced Postischemic Functional Recovery in CYP2J2 Transgenic Hearts Involves Mitochondrial ATP-Sensitive K+ Channels and p42/p44 MAPK Pathway
Together, these data suggest that CYP2J2-derived metabolites are cardioprotective after ischemia, and the mechanism for thisCardioprotection involves activation of mitoKATP and p42/p44 MAPK.
Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4
- P. Blackshear, J. Graves, D. Stumpo, I. Cobos, J. Rubenstein, D. Zeldin
- Biology, MedicineDevelopment
- 1 October 2003
Data implicate the RFX4_v3 variant transcript as being crucial for early brain development, as well as for the genesis of the subcommissural organ, a structure important for cerebrospinal fluid flow through the aqueduct of Sylvius, and resulted in congenital hydrocephalus.
Cloning of CYP2J2 gene and identification of functional polymorphisms.
It is concluded that allelic variants of the human CYP2J2 gene exist and that some of these variants result in a P450 protein that has reduced catalytic function.
Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia‐reperfusion injury in isolated mouse heart
It is demonstrated that increased ROS generation and enhanced DiHOME synthesis by endothelial CYP2C8 impair functional recovery and mask the beneficial effects of increased EET production following I/R.
Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension‐induced renal injury in mice
- Craig R. Lee, J. Imig, D. Zeldin
- Biology, MedicineFASEB journal : official publication of the…
- 1 October 2010
It is concluded that endothelial CYP epoxygenase function contributes to the regulation of blood pressure and renal injury in mice.
Cardiac and vascular KATP channels in rats are activated by endogenous epoxyeicosatrienoic acids through different mechanisms
The effects of AA on KATP channels in freshly isolated cardiac myocytes from rats, wild‐type (WT) and transgenic mice overexpressing CYP2J2 cDNA, and mesenteric arterial smooth muscle cells from rats are examined.
Spontaneous Airway Hyperresponsiveness in Estrogen Receptor-α–deficient Mice
Estrogen receptor-α knockout mice exhibit a variety of lung function abnormalities and have enhanced airway responsiveness to inhaled methacholine and serotonin under basa...
Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities.
The organization of the mouse Cyp2c locus is described, which contains 15 genes and four pseudogenes, all of which are located in a 5-megabase region on chromosome 19, and it is concluded that these new CYP2C enzymes are probably involved in AA and linoleic acid metabolism in mouse hepatic and extrahepatic tissues.
Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice
- Yangmei Deng, M. Edin, Craig R. Lee
- BiologyFASEB journal : official publication of the…
- 1 February 2011
It is demonstrated that potentiation of the CYP epoxygenase pathway by either increased endothelial EET biosynthesis or globally decreased EET hydrolysis attenuates NF‐κB‐dependent vascular inflammatory responses in vivo and may serve as a viable anti‐inflammatory therapeutic strategy.
Spontaneous airway hyperresponsiveness in estrogen receptor-alpha-deficient mice.
Estrogen receptor-alpha knockout mice exhibit a variety of lung function abnormalities and have enhanced airway responsiveness to inhaled methacholine and serotonin under basal conditions, suggesting that estrogen receptor- alpha is a critical regulator of airway hyperresponsiveness in mice.