• Publications
  • Influence
Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1
Type I interferons are important in regulating immune responses to pathogens and tumors. All interferons are considered to signal via the heterodimeric IFNAR1-IFNAR2 complex, yet some subtypes suchExpand
  • 177
  • 12
Functional Crosstalk between Type I and II Interferon through the Regulated Expression of STAT1
Small "priming" quantities of type I interferon enhance cellular responses to type II interferon by maintaining basal levels of STAT1, explaining the observed crosstalk between these two cytokines.
  • 139
  • 11
  • Open Access
Regulation of Pdha-2 expression is mediated by proximal promoter sequences and CpG methylation.
Spermatogenesis is a complex process requiring the coordinate expression of a number of testis-specific genes. One of these, Pdha-2, codes for the murine spermatogenesis-specific isoform of the E1aExpand
  • 67
  • 7
Suppressor of Cytokine Signaling (SOCS) 1 Inhibits Type I Interferon (IFN) Signaling via the Interferon α Receptor (IFNAR1)-associated Tyrosine Kinase Tyk2*
Type I IFNs are critical players in host innate and adaptive immunity. IFN signaling is tightly controlled to ensure appropriate immune responses as imbalance could result in uncontrolledExpand
  • 108
  • 7
Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape
Breast cancer metastasis is a key determinant of long-term patient survival. By comparing the transcriptomes of primary and metastatic tumor cells in a mouse model of spontaneous bone metastasis, weExpand
  • 270
  • 6
Bacterial Phosphorylcholine Decreases Susceptibility to the Antimicrobial Peptide LL-37/hCAP18 Expressed in the Upper Respiratory Tract
ABSTRACT A number of pathogens of the upper respiratory tract express an unusual prokaryotic structure, phosphorylcholine (ChoP), on their cell surface. We tested the hypothesis that ChoP, also foundExpand
  • 169
  • 6
Mal Interacts with Tumor Necrosis Factor Receptor-associated Factor (TRAF)-6 to mediate NF-κB Activation by Toll-like Receptor (TLR)-2 and TLR4*
The Toll-interleukin-1 receptor domain-containing adapter Mal (MyD88 adapter-like protein) is involved in Toll-like receptor (TLR)-2 and TLR4 signal transduction. However, no studies have yetExpand
  • 110
  • 5
Hypothyroidism after treatment with interleukin-2 and lymphokine-activated killer cells.
The development of a goiter and hypothyroidism in a 28-year-old man in whom metastatic melanoma had been treated with interleukin-2 and lymphokine-activated killer cells (LAK cells) prompted us toExpand
  • 294
  • 3
CiiiDER: A tool for predicting and analysing transcription factor binding sites
tl;dr
We present CiiiDER, an integrated computational toolkit for transcription factor binding analysis, written in the Java programming language, to make it independent of computer operating system. Expand
  • 10
  • 3
Phase I evaluation of recombinant interleukin-2 in patients with advanced malignant disease.
Seventeen patients with refractory malignant tumors were treated with recombinant human interleukin-2 (IL-2) administered by weekly bolus intravenous (IV) injection in a phase I dose escalationExpand
  • 142
  • 2