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Frailty in older adults: evidence for a phenotype.
This study provides a potential standardized definition for frailty in community-dwelling older adults and offers concurrent and predictive validity for the definition, and finds that there is an intermediate stage identifying those at high risk of frailty. Expand
Burden of valvular heart diseases: a population-based study
Moderate or severe valvular heart diseases are notably common in this population and increase with age and in the community, women are less often diagnosed than are men, which could indicate an important imbalance in view of the associated lower survival. Expand
Clinical Factors Associated With Calcific Aortic Valve Disease
Clinical factors associated with aortic sclerosis and stenosis can be identified and are similar to risk factors for atherosclerosis. Expand
Predictors of congestive heart failure in the elderly: the Cardiovascular Health Study.
The incidence of CHF is high in the elderly and is related mainly to age, gender, clinical and subclinical coronary heart disease, systolic BP and inflammation, which is a leading source of morbidity and mortality in this group. Expand
Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study.
The hypothesis that there is a specific physiological basis to the geriatric syndrome of frailty that is characterized in part by increased inflammation and elevated markers of blood clotting is supported and that these physiological differences persist when those with diabetes and cardiovascular disease are excluded. Expand
Recommendations for evaluation of prosthetic valves with echocardiography and doppler ultrasound: a report From the American Society of Echocardiography's Guidelines and Standards Committee and the
A Report From the American Society of Echocardiography’s Guidelines and Standards Committee and the Task Force on Prosthetic Valves, Developed in Conjunction With the American College of CardiologyExpand
HIV infection and the risk of acute myocardial infarction.
Investigating whether HIV is associated with an increased risk of acute myocardial infarction after adjustment for all standard Framingham risk factors among a large cohort of HIV-positive and demographically and behaviorally similar uninfected veterans in care found infections with HIV are associated with a 50% increased risk beyond that explained by recognized risk factors. Expand
Associations of subclinical cardiovascular disease with frailty.
Cardiovascular disease was associated with an increased likelihood of frail health and infarct-like lesions in the brain on magnet resonance imaging were related to frailty as well. Expand
Association of serial measures of cardiac troponin T using a sensitive assay with incident heart failure and cardiovascular mortality in older adults.
To determine if cardiac troponin T (cTnT) measured by a highly sensitive assay would be detectable in the majority of community-dwelling older adults, and if serial measures were associated with risk of HF hospitalization and cardiovascular death, a cohort of older adults without known HF was studied. Expand