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Assessment of insight in psychosis.
The Scale to Assess Unawareness of Mental Disorder has good reliability and validity and has certain advantages over previous measures of insight, suggesting the usefulness of a multidimensional view of this complex concept. Expand
Multicenter collaborative panic disorder severity scale.
The Panic Disorder Severity Scale is a simple, efficient way for clinicians to rate severity in patients with established diagnoses of panic disorder, however, further research with more diverse groups ofpanic disorder patients and with a broader range of convergent and discriminant validity measures is needed. Expand
Awareness of illness in schizophrenia and schizoaffective and mood disorders.
It is suggested that severe self-awareness deficits are a prevalent feature of schizophrenia, perhaps stemming from the neuropsychological dysfunction associated with the disorder, and are more common in schizophrenia than in other psychotic disorders. Expand
Neuroanatomical hypothesis of panic disorder, revised.
Medications, particularly those that influence the serotonin system, are hypothesized to desensitize the fear network from the level of the amygdala through its projects to the hypothalamus and the brainstem, and effective psychosocial treatments may also reduce contextual fear and cognitive misattributions. Expand
Increased baseline occupancy of D2 receptors by dopamine in schizophrenia.
Elevated synaptic dopamine was predictive of good treatment response of positive symptoms to antipsychotic drugs and increased stimulation of D(2) receptors by dopamine in schizophrenia, consistent with increased phasic activity of dopaminergic neurons. Expand
Cognitive-behavioral therapy, imipramine, or their combination for panic disorder: A randomized controlled trial.
Combining imipramine and CBT appeared to confer limited advantage acutely but more substantial advantage by the end of maintenance, and each treatment worked well immediately following treatment and during maintenance;CBT appeared durable in follow-up. Expand
Prefrontal Dopamine D1 Receptors and Working Memory in Schizophrenia
Findings confirm that alteration of DLPFC D1 receptor transmission is involved in working memory deficits presented by patients with schizophrenia. Expand
Awareness of illness in schizophrenia.
The argument is made here that many of the self-awareness deficits observed in schizophrenia are of diagnostic significance, are neurally based, and are indispensable in guiding treatment decisions. Expand
The National Depressive and Manic-Depressive Association consensus statement on the undertreatment of depression.
There is overwhelming evidence that individuals with depression are being seriously undertreated and the cost to individuals and society of this undertreatment is substantial. Expand
Neuroanatomical Hypothesis of Panic Disorder, Revised
Objective: In a 1989 article, the authors provided a hypothesis for the neuroanatomical basis of panic disorder that attempted to explain why both medication and cognitive behavioral psychotherapyExpand