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QIIME allows analysis of high-throughput community sequencing data
TLDR
An overview of the analysis pipeline and links to raw data and processed output from the runs with and without denoising are provided. Expand
An obesity-associated gut microbiome with increased capacity for energy harvest
TLDR
It is demonstrated through metagenomic and biochemical analyses that changes in the relative abundance of the Bacteroidetes and Firmicutes affect the metabolic potential of the mouse gut microbiota and indicates that the obese microbiome has an increased capacity to harvest energy from the diet. Expand
A core gut microbiome in obese and lean twins
TLDR
The faecal microbial communities of adult female monozygotic and dizygotic twin pairs concordant for leanness or obesity, and their mothers are characterized to address how host genotype, environmental exposure and host adiposity influence the gut microbiome. Expand
Microbial ecology: Human gut microbes associated with obesity
TLDR
It is shown that the relative proportion of Bacteroidetes is decreased in obese people by comparison with lean people, and that this proportion increases with weight loss on two types of low-calorie diet. Expand
Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencing
TLDR
It is demonstrated that high-quality read length and abundance are the primary factors differentiating correct from erroneous reads produced by Illumina GAIIx, HiSeq and MiSeq instruments. Expand
Human gut microbiome viewed across age and geography
TLDR
The need to consider the microbiome when evaluating human development, nutritional needs, physiological variations and the impact of westernization is underscored, as distinctive features of the functional maturation of the gut microbiome are evident in early infancy as well as adulthood. Expand
Obesity alters gut microbial ecology.
TLDR
Analysis of the microbiota of genetically obese ob/ob mice, lean ob/+ and wild-type siblings, and their ob/+ mothers, all fed the same polysaccharide-rich diet, indicates that obesity affects the diversity of the gut microbiota and suggests that intentional manipulation of community structure may be useful for regulating energy balance in obese individuals. Expand
The gut microbiota as an environmental factor that regulates fat storage.
TLDR
It is found that conventionalization of adult germ-free (GF) C57BL/6 mice with a normal microbiota harvested from the distal intestine of conventionally raised animals produces a 60% increase in body fat content and insulin resistance within 14 days despite reduced food intake. Expand
Evolution of Mammals and Their Gut Microbes
TLDR
It is indicated that host diet and phylogeny both influence bacterial diversity, which increases from carnivory to omnivory to herbivory; that bacterial communities codiversified with their hosts; and that the gut microbiota of humans living a modern life-style is typical of omnivorous primates. Expand
Bacterial Community Variation in Human Body Habitats Across Space and Time
TLDR
The results indicate that the microbiota, although personalized, varies systematically across body habitats and time; such trends may ultimately reveal how microbiome changes cause or prevent disease. Expand
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