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Cloning and characterization of a mammalian proton-coupled metal-ion transporter
A new metal-ion transporter in the rat, DCT1, which has an unusually broad substrate range that includes Fe2+, Zn2+, Mn2+, Co2+, Cd2+, Cu2+, Ni2+ and Pb2+.
Receptor for albumin on the liver cell surface may mediate uptake of fatty acids and other albumin-bound substances.
Kinetic analysis of the uptake of carbon-14-labeled oleate in a single-pass perfusion of rat liver and saturable and specific binding of iodine-125-labeled albumin to hepatocytes in suspension…
Alcohol Metabolism-mediated Oxidative Stress Down-regulates Hepcidin Transcription and Leads to Increased Duodenal Iron Transporter Expression*
- D. Harrison-Findik, D. Schafer, +7 authors J. Gollan
- Chemistry, MedicineJournal of Biological Chemistry
- 11 August 2006
Findings indicate that alcohol metabolism-mediated oxidative stress regulates hepcidin transcription via C/EBPα, which in turn leads to increased duodenal iron transport.
Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents.
Endotoxin inhibits hepatocellular sodium-dependent bile salt uptake by decreasing both expression of Ntcp and activity of the Na+,K-ATPase.
Tumor necrosis factor–alpha decreases hepatocyte bile salt uptake and mediates endotoxin‐induced cholestasis
The role of TNFα in the pathogenesis of endotoxin‐induced cholestasis in intact animals, and in the uptake of taurocholate by cultured hepatocytes is investigated, postulate that TNF α is an important mediator of the cholESTasis of sepsis.
Wilson disease in 1998: genetic, diagnostic and therapeutic aspects.
Iron‐mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol
- D. Harrison-Findik, Elizabeth B. Klein, C. Crist, John Evans, N. Timchenko, J. Gollan
- Biology, MedicineHepatology
- 1 December 2007
It is suggested that alcohol negates the protective effect of hepcidin, which may have implications for the liver injury observed in alcoholic liver disease and genetic hemochromatosis in combination with alcohol.
Ryanodine-induced calcium release from hepatic microsomes and permeabilized hepatocytes.
It is concluded that ryanodine is capable of mobilizing Ca2+ in the hepatocyte from microsomal stores that are distinct from those that can be regulated by Ins(1,4,5)P3 but that cADPR has no such effect.
Performance characteristics and results of a large‐scale screening program for viral hepatitis and risk factors associated with exposure to viral hepatitis B and C: Results of the National Hepatitis…
It is practical to consider screening for HBV and HCV in the United States, particularly if any risk factor is present, and improved treatment strategies will make screening even more cost effective.
Regulation of hepatocyte bile salt transporters during hepatic regeneration.
- R. Green, J. Gollan, B. Hagenbuch, P. Meier, D. Beier
- Biology, MedicineThe American journal of physiology
- 1 September 1997
Partial hepatectomy results in a marked reduction in the gene transcription and expression of the liver-specific Ntcp, as well as a decrease in protein expression and loss of transport activity, which provide a potential mechanism for the decrease in hepatocellular bile salt transport that is associated with hepatic regeneration.