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Myosin vb is associated with plasma membrane recycling systems.
TLDR
The results indicate myosin Vb is associated with the plasma membrane recycling system in nonpolarized cells and the apical recyclingSystem in polarized cells, and the dominant negative effects of the myosIn Vb tail chimera indicate that this unconventional myos in is required for transit out of plasma membranes recycling systems. Expand
Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells.
TLDR
It is reported that in the epithelial cell line Madin-Darby Canine Kidney (MDCK), antibodies to Rab11a label an apical pericentriolar endosomal compartment that is dependent on intact microtubules for its integrity and suggests that Rab25 may selectively regulate the apical recycling and/or transcytotic pathways. Expand
Gastric Cancer Originating from Bone Marrow-Derived Cells
TLDR
It is shown that although acute injury, acute inflammation, or transient parietal cell loss within the stomach do not lead to BMDC recruitment, chronic infection of C57BL/6 mice with Helicobacter induces repopulation of the stomach with BMDCs, suggesting that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression. Expand
Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm
TLDR
It is suggested that Sox2 plays a second role in establishing the boundary between the keratinized, squamous esophagus/forestomach and glandular hindstomach, and FGF signaling from the ventral mesenchyme regulates Sox2 expression in the endoderm. Expand
Identification and Characterization of a Family of Rab11-interacting Proteins*
TLDR
The results suggest that the function of Rab11a in plasma membrane recycling systems is dependent upon a compendium of protein effectors. Expand
Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice.
TLDR
Histochemical study revealed severe anatomic disruption of the cochlear and vestibular end organs, suggesting that Kvlqt1 is essential for normal development of the inner ear, and there were no features of BWS, suggest that KvLQT1 is not responsible for BWS. Expand
Regulation of Vesicle Trafficking in Madin-Darby Canine Kidney Cells by Rab11a and Rab25*
TLDR
It is indicated that neither Rab11a nor Rab25 function in the basolateral recycling of transferrin in polarized Madin-Darby canine kidney cells cells, consistent with recent morphological observations by others. Expand
Ezrin is a cyclic AMP‐dependent protein kinase anchoring protein
TLDR
It is demonstrated that ezrin is a major AKAP in gastric parietal cells and may function to tether type II A‐kinase to a region near the secretory canaliculus. Expand
Rab11 Family Interacting Protein 2 Associates with Myosin Vb and Regulates Plasma Membrane Recycling*
TLDR
The ternary association of myosin Vb and Rab11-FIP2 with Rab11a suggests that a multimeric protein complex is involved in vesicle trafficking through plasma membrane recycling systems. Expand
Alternative Splicing in Class V Myosins Determines Association with Rab10*
TLDR
The results indicate that Rab GTPases regulate diverse endocytic trafficking pathways through recruitment of multiple myosin V isoforms. Expand
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