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A surface protease and the invasive character of plague.
- O. A. Sodeinde, Y. Subrahmanyam, K. Stark, T. Quan, Y. Bao, J. Goguen
- Biology, Medicine
- 6 November 1992
A 9.5-kilobase plasmid of Yersinia pestis, the causative agent of plague, is required for high virulence when mice are inoculated with the bacterium by subcutaneous injection. Inactivation of the… Expand
Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response
At mammalian body temperature, the plague bacillus Yersinia pestis synthesizes lipopolysaccharide (LPS)–lipid A with poor Toll-like receptor 4 (TLR4)–stimulating activity. To address the effect of… Expand
Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death
- Dan Weng, Robyn Marty-Roix, +15 authors E. Lien
- Medicine, Biology
- Proceedings of the National Academy of Sciences
- 5 May 2014
Significance Receptor-interacting protein-1 (RIP1) kinase and caspase-8 are important players in activation of apoptotic pathways. Here we show that RIP1, caspase-8, and RIP3 contribute to… Expand
The NLRP12 inflammasome recognizes Yersinia pestis.
Yersinia pestis, the causative agent of plague, is able to suppress production of inflammatory cytokines IL-18 and IL-1β, which are generated through caspase-1-activating nucleotide-binding domain… Expand
Fibrin and fibrinolysis in infection and host defense
- J. Degen, T. Bugge, J. Goguen
- Medicine, Biology
- Journal of thrombosis and haemostasis : JTH
- 1 July 2007
Summary. Bacterial pathogens have frequently evolved and maintained the capacity to engage and/or activate hemostatic system components of their vertebrate hosts. Recent studies of mice with… Expand
Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death
Caspase-8 is a player in pyroptosis The activation of certain pattern-recognition receptors by pathogen-associated molecular patterns results in the formation of inflammasome complexes. Inflammasome… Expand
Genetic analysis of the low calcium response in Yersinia pestis mu d1(Ap lac) insertion mutants.
Yersinia pestis strain KIM requires plasmid pCD1 for expression of the low calcium response, plague virulence antigen V, and virulence. We constructed Mu d1(Ap lac) insertion mutants of this plasmid… Expand
Temperature sensing in Yersinia pestis: translation of the LcrF activator protein is thermally regulated.
The lcrF gene of Yersinia pestis encodes a transcription activator responsible for inducing expression of several virulence-related proteins in response to temperature. The mechanism of this… Expand
RNA expression patterns change dramatically in human neutrophils exposed to bacteria.
A comprehensive study of changes in messenger RNA (mRNA) levels in human neutrophils following exposure to bacteria is described. Within 2 hours there are dramatic changes in the levels of several… Expand
Genetic analysis of the 9.5-kilobase virulence plasmid of Yersinia pestis.
The 9.5-kilobase plasmid of Yersinia pestis determines plasminogen activator, coagulase, pesticin, and pesticin immunity activities. We have mapped and cloned the loci encoding these activities and… Expand