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Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
TLDR
It is shown that the C/C genotype strongly enhances resolution of HCV infection among individuals of both European and African ancestry, the strongest and most significant genetic effect associated with natural clearance ofHCV.
Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene
TLDR
The CKR5Δ32 deletion may act as a recessive restriction gene against HIV-1 infection and may exert a dominant phenotype of delaying progression to AIDS among infected individuals.
Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS
TLDR
The strongest synergistic effect of these loci was on progression to depletion of CD4+ T cells, which suggests that a protective response of NK cells involving KIR3DS1 and its HLA class I ligands begins soon after HIV-1 infection.
HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage.
TLDR
The extended survival of 28 to 40 percent of HIV-1-infected Caucasian patients who avoided AIDS for ten or more years can be attributed to their being fully heterozygous at HLA class I loci, to their lacking the AIDS-associated alleles B*35 and Cw*04, or to both.
HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection
TLDR
The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV.
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1
TLDR
The various epistatic effects observed here for common, distinct KIR3DL1 and HLA-B Bw4 combinations are unprecedented with regard to any pair of genetic loci in human disease, and indicate that NK cells may have a critical role in the natural history of HIV infection.
Human papillomavirus-associated cancers in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome.
TLDR
HPV-associated malignancies occur at increased rates in persons with HIV/AIDS, and increasing RRs for in situ cancers to and beyond the time of AIDS onset may reflect the gradual loss of control over HPV-infected keratinocytes with advancing immunosuppression.
Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter
TLDR
Genetic association analysis of five acquired immunodeficiency syndrome (AIDS) cohorts revealed that although CCR2-64I exerts no influence on the incidence of HIV- 1 infection, HIV-1-infected individuals carrying the C CR2- 64I allele progressed to AIDS 2 to 4 years later than individuals homozygous for the common allele.
Trends in cancer risk among people with AIDS in the United States 1980–2002
TLDR
Dramatic declines in KS and NHL were temporally related to improving therapies, especially introduction of HAART, but those with AIDS remain at marked risk of cancer.
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