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Variability, compensation and homeostasis in neuron and network function
TLDR
Examples from theoretical and experimental studies of invertebrates and vertebrates are used to explore several issues relevant to understanding the precision of tuning of synaptic and intrinsic currents for the operation of functional neuronal circuits.
Variable channel expression in identified single and electrically coupled neurons in different animals
TLDR
Measurements of channel expression in the two electrically coupled pyloric dilator neurons showed significant interanimal variability, but copy numbers for IH (encoding the hyperpolarization-activated, inward-current channel) and Shal mRNA in theTwo PD neurons from the same crab were similar, suggesting that the regulation of some currents may be shared in electrically coupling neurons.
How Multiple Conductances Determine Electrophysiological Properties in a Multicompartment Model
TLDR
C cubic fits of the function from maximal conductances to a series of electrophysiological properties to ask which conductances predominantly influence input conductance, resting membrane potential, resting spike rate, phasing of activity in response to rhythmic inhibition, and several other properties can be used to understand how multiple currents in any candidate neuron interact to determine the cell's electrophYSiological behavior.
Functional consequences of animal-to-animal variation in circuit parameters
TLDR
There was considerable preparation-to-preparation variability in the strength of two identified synapses, in the amplitude of a modulator-evoked current and in the expression of six ion channel genes, but strong correlations across preparations among these parameters and attributes of circuit performance were found.
Quantitative expression profiling of identified neurons reveals cell-specific constraints on highly variable levels of gene expression
TLDR
By measuring absolute mRNA levels of six different channels in the same individually identified neurons, it is demonstrated that not only do individual cell types possess highly variable levels of channel expression but that this variability is constrained by unique patterns of correlated channel expression.
Activity-Dependent Presynaptic Effect of Serotonin 1B Receptors on the Somatosensory Thalamocortical Transmission in Neonatal Mice
TLDR
In the developing barrel field of the neonatal mice, 5-HT1B receptors mediate an activity-dependent regulation of the TC EPSC that could favor the propagation of high-frequency TC activity.
Ca2+/cAMP-Sensitive Covariation of IA and IH Voltage Dependences Tunes Rebound Firing in Dopaminergic Neurons
TLDR
It is proposed that the covariation of voltage dependences of ion channels represents a flexible and energy-efficient way of tuning firing in neurons.
Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development
TLDR
No robust differences in voltage‐gated ion channel immunolabeling were observed across the population of SNc dopaminergic neurons for each age examined, suggesting that differing levels of individual ion channels are unlikely to distinguish between specific subpopulations ofSNc dopaminaergic neurons.
Octopamine Modulates the Axons of Modulatory Projection Neurons
TLDR
Octopamine increases the cycle frequency of the pyloric rhythm in the crab Cancer borealis by acting at multiple sites within the stomatogastric nervous system, including the axons of identified modulatory neurons that project to the STG.
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