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A Single Ascending Dose Study of Epigallocatechin Gallate in Healthy Volunteers
Single oral doses of EGCG up to 1600 mg were safe and very well tolerated and revealed rapid absorption with a one-peak plasma concentration versus time course, followed by a multiphasic decrease consisting of a distribution phase and an elimination phase. Expand
Multiple-dose pharmacokinetics of ritonavir in human immunodeficiency virus-infected subjects
Constant concentration-dependent autoinduction is the most likely mechanism for the time-dependent pharmacokinetics of ritonavir, and the levels were correlated with baseline triglyceride levels and AUC, Cmax, or predose concentrations. Expand
Plasma-kinetic characteristics of purified and isolated green tea catechin epigallocatechin gallate (EGCG) after 10 days repeated dosing in healthy volunteers.
Ten days' repeated administration of oral doses of EGCG of up to 800 mg per day were found to be safe and very well tolerated. Expand
Bioavailability of melatonin in humans after day-time administration of D(7) melatonin.
Absolute bioavailability of the neurohormone melatonin was studied in 12 young healthy volunteers and pharmacokinetic parameters used to quantify bioavailability were near three-fold greater in female subjects than in males, with large inter-individual variations. Expand
[Pharmacokinetic properties of Bilobalide and Ginkgolides A and B in healthy subjects after intravenous and oral administration of Ginkgo biloba extract (EGb 761)].
The pharmacokinetics of GinkGolide A, Ginkgolide B and Bilobalide, which are compounds extracted from the dried leaves of the Ginkgo biloba tree, were investigated in 12 young healthy volunteers after single-dose administration of Ginkinggo Biloba extract. Expand
Melatonin secretion occurs at a constant rate in both young and older men and women.
The magnitude and duration of melatonin (MLT) secretion were measured over a period of 25 h with pharmacokinetic studies employing administration of D(7) MLT at midday and at midnight in two separateExpand
Phase I Study of percutaneous 4-hydroxy-tamoxifen with analyses of 4-hydroxy-tamoxifen concentrations in breast cancer and normal breast tissue
Percutaneous 4-OH-TAM cannot be proposed as an alternative tamoxifen treatment and classic effects on coagulation and lipid metabolism when pre- and post-treatment values of these biological variables were compared, whereas no difference was observed in the percutaneous group. Expand
Serum levels and urinary excretion of mequitazine after a single oral dose.
The results suggested that after the oral administration only low mequitazine concentrations appeared in serum, most of the drug seemed to be deactivated by the extrarenal route, and the kinetic properties of the the drug resembled those of several phenothiazines used for psychiatric therapy. Expand
Fluorometric high-performance liquid chromatographic determination of sotalol in biological fluids.
High-performance liquid chromatographic (HPLC), which allows more rapid analysis of plasma sotalol levels than does GLC, appears suitable for pharmacokinetic studies as well as for therapeutic drug monitoring. Expand
Determination of calcium acetylhomotaurinate in human plasma and urine by combined gas chromatography-negative-ion chemical ionization mass spectrometry.
A highly sensitive and specific assay has been developed for the determination of calcium acetylhomotaurinate and the internal standard (LM 3041) at the picomole level in human plasma and urine byExpand