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Seasonal affective disorder. A description of the syndrome and preliminary findings with light therapy.
Seasonal affective disorder (SAD) is a syndrome characterized by recurrent depressions that occur annually at the same time each year. We describe 29 patients with SAD; most of them had a bipolarExpand
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Automatic sleep/wake identification from wrist activity.
The purpose of this study was to develop and validate automatic scoring methods to distinguish sleep from wakefulness based on wrist activity. Forty-one subjects (18 normals and 23 with sleep orExpand
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Sleep and psychiatric disorders. A meta-analysis.
We reviewed the literature on sleep in psychiatric disorders and evaluated the data by meta-analysis, a statistical method designed to combine data from different studies. A total of 177 studies withExpand
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TEMPS-A: validation of a short version of a self-rated instrument designed to measure variations in temperament.
OBJECTIVE To validate a short English-language version of the Temperament Evaluation of Memphis, Pisa, Paris and San Diego-autoquestionnaire version (TEMPS-A), a self-report questionnaire designed toExpand
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Altered brain response to verbal learning following sleep deprivation
The effects of sleep deprivation on the neural substrates of cognition are poorly understood. Here we used functional magnetic resonance imaging to measure the effects of 35 hours of sleepExpand
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Effects of sleep and sleep deprivation on interleukin-6, growth hormone, cortisol, and melatonin levels in humans.
The objective of this study was to evaluate the effects of nocturnal sleep, partial night sleep deprivation, and sleep stages on circulating concentrations of interleukin-6 (IL-6) in relation to theExpand
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The sleep of abstinent pure primary alcoholic patients: natural course and relationship to relapse.
Sleep in male pure primary alcoholic inpatients was examined at a mean of 16 days (n = 29), 19 weeks (n = 29), 14 months (n = 9), and 27 months (n = 4) of abstinence. Results were as follows: (1) theExpand
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Partial night sleep deprivation reduces natural killer and celhdar immune responses in humans
Prolonged and severe sleep deprivation is associated with alterations of natural and cellular immune function. To determine whether alterations of immune function also occur after even a modest lossExpand
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Increased cerebral response during a divided attention task following sleep deprivation
We recently reported that the brain showed greater responsiveness to some cognitive demands following total sleep deprivation (TSD). Specifically, verbal learning led to increased cerebral activationExpand
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Magnetic resonance imaging and mood disorders. Localization of white matter and other subcortical abnormalities.
BACKGROUND Recent reports in the literature document an association between focal white matter abnormalities in bipolar as well as unipolar mood disorder. The importance of this finding and otherExpand
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