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Respiring mitochondria determine the pattern of activation and inactivation of the store‐operated Ca2+ current ICRAC
In eukaryotic cells, hormones and neurotransmitters that engage the phosphoinositide pathway evoke a biphasic increase in intracellular free Ca2+ concentration: an initial transient release of Ca2+Expand
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Energized mitochondria increase the dynamic range over which inositol 1,4,5‐trisphosphate activates store‐operated calcium influx
In eukaryotic cells, activation of cell surface receptors that couple to the phosphoinositide pathway evokes a biphasic increase in intracellular free Ca2+ concentration: an initial transient phaseExpand
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The mechanism of calcium channel facilitation in bovine chromaffin cells.
1. This study was planned to clarify the mechanism of Ca2+ channel facilitation by depolarizing prepulses given to voltage‐clamped bovine chromaffin cells. The hypothesis for an autocrine modulationExpand
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ATP from Subplasmalemmal Mitochondria Controls Ca2+-dependent Inactivation of CRAC Channels*
A sustained Ca2+ entry is the primary signal for T lymphocyte activation after antigen recognition. This Ca2+ entry mainly occurs through store-operated Ca2+ channels responsible for a highlyExpand
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Blocking effects of otilonium on Ca2+ channels and secretion in rat chromaffin cells.
We describe here the effects of otilonium bromide (an anticholinergic agent widely used as an intestinal spasmolytic) on whole-cell currents through Ca2+ channels (IBa) and catecholamine secretion inExpand
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Otilonium: a potent blocker of neuronal nicotinic ACh receptors in bovine chromaffin cells
1 Otilonium, a clinically useful spasmolytic, behaves as a potent blocker of neuronal nicotinic acetylcholine receptors (AChR) as well as a mild wide‐spectrum Ca2+ channel blocker in bovine adrenalExpand
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Cytoplasmic calcium buffering.
  • J. Gilabert
  • Chemistry, Medicine
  • Advances in experimental medicine and biology
  • 2012
Calcium buffering is one of the mechanisms to control calcium (Ca(2+)) persistence in the cytosol and hence, Ca(2+) dependence of many intracellular processes. Compared with Ca(2+) sequestration intoExpand
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Alterations in the coagulation and fibrinolysis system in pregnancy, labour and puerperium, with special reference to a possible transitory state of intravascular coagulation during labour.
: Various tests of hemostasis were carried out during pregancy, labour and the puerperium in a group of 259 women. Determinations were carried out in the 1st, 2nd and 3rd trimesters, in the period ofExpand
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Plasminogen Activator Inhibitor-1 (PAI-1) Promoter 4G/5G Genotype and Increased PAI-1 Circulating Levels in Postmenopausal Women with Coronary Artery Disease Influence of Hormone Replacement Therapy
Increased circulating levels of type 1 plasminogen activator inhibitor (PAI-1) have been associated with coronary artery disease (CAD). However, genetic and environmental determinants of PAI-1Expand
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Activated protein C:α1-antitrypsin (APC:α1AT) complex as a marker for in vitro diagnosis of prethrombotic states
Abstract The purpose of the study was to test whether APC: α 1 AT complex is a useful clinical marker of the activation of coagulation. The rationale for this is that activated protein C may appearExpand
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