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The Fc receptor γ‐chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen
Activation of mouse platelets by collagen is associated with tyrosine phosphorylation of multiple proteins including the Fc receptor γ‐chain, the tyrosine kinase Syk and phospholipase Cγ2, suggestingExpand
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A role for the thiol isomerase protein ERP5 in platelet function.
Formation and rearrangement of disulfide bonds during the correct folding of nascent proteins is modulated by a family of enzymes known as thiol isomerases, which include protein disulfide isomeraseExpand
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The p85 Subunit of Phosphatidylinositol 3-Kinase Associates with the Fc Receptor γ-Chain and Linker for Activitor of T Cells (LAT) in Platelets Stimulated by Collagen and Convulxin*
There is extensive evidence to show that phosphatidylinositol 3-kinase plays an important role in signaling by the immune family of receptors, which has recently been extended to include the plateletExpand
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Platelet adhesion signalling and the regulation of thrombus formation
  • J. Gibbins
  • Biology, Medicine
  • Journal of Cell Science
  • 15 July 2004
Platelets perform a central role in haemostasis and thrombosis. They adhere to subendothelial collagens exposed at sites of blood vessel injury via the glycoprotein (GP) Ib-V-IX receptor complex,Expand
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Nongenomic signaling of the retinoid X receptor through binding and inhibiting Gq in human platelets
Retinoid X receptors (RXRs) are important transcriptional nuclear hormone receptors, acting as either homodimers or the binding partner for at least one fourth of all the known human nuclearExpand
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In vivo selection for metastasis promoting genes in the mouse
Here, we report the identification of a metastasis promoting factor by a forward genetic screen in mice. A retroviral cDNA library was introduced into the nonmetastatic cancer cell line 168FARN,Expand
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Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice.
Protein disulfide isomerase (PDI) derived from intravascular cells is required for thrombus formation. However, it remains unclear whether platelet PDI contributes to the process. UsingExpand
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A structural basis for the inhibition of collagen‐stimulated platelet function by quercetin and structurally related flavonoids
Background and purpose:  Molecular mechanisms underlying the links between dietary intake of flavonoids and reduced cardiovascular disease risk are only partially understood. Key events in theExpand
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Platelet signaling: a complex interplay between inhibitory and activatory networks
The role of platelets in hemostasis and thrombosis is dependent on a complex balance of activatory and inhibitory signaling pathways. Inhibitory signals released from the healthy vasculature suppressExpand
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Platelet PECAM-1 inhibits thrombus formation in vivo.
Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a cell surface glycoprotein receptor expressed on a range of blood cells, including platelets, and on vascular endothelial cells. PECAM-1Expand
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