• Publications
  • Influence
Multimodular Penicillin-Binding Proteins: An Enigmatic Family of Orthologs and Paralogs
  • C. Goffin, J. Ghuysen
  • Biology, Medicine
  • Microbiology and Molecular Biology Reviews
  • 1 December 1998
SUMMARY The monofunctional penicillin-binding dd-peptidases and penicillin-hydrolyzing serine β-lactamases diverged from a common ancestor by the acquisition of structural changes in the polypeptideExpand
  • 590
  • 46
  • PDF
A standard numbering scheme for the class A beta-lactamases.
  • 943
  • 27
Biochemistry and Comparative Genomics of SxxK Superfamily Acyltransferases Offer a Clue to the Mycobacterial Paradox: Presence of Penicillin-Susceptible Target Proteins versus Lack of Efficiency of
  • C. Goffin, J. Ghuysen
  • Biology, Medicine
  • Microbiology and Molecular Biology Reviews
  • 1 December 2002
SUMMARY The bacterial acyltransferases of the SxxK superfamily vary enormously in sequence and function, with conservation of particular amino acid groups and all-α and α/β folds. They occur asExpand
  • 185
  • 14
  • PDF
Serine beta-lactamases and penicillin-binding proteins.
  • J. Ghuysen
  • Medicine
  • Annual review of microbiology
  • 1991
  • 173
  • 12
Serine beta-lactamases and penicillin-binding proteins.
The Penicillin-Interactive, Active-Site Serine Protein Family . . . . . .... . . . . .. . . . . . . . . . . . . . 37 The Low-Mr PBPs . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . .Expand
  • 474
  • 10
Lack of Cell Wall Peptidoglycan versus Penicillin Sensitivity: New Insights into the Chlamydial Anomaly
Intracellular bacterial pathogens enter their hosts surrounded by a membrane-bound vacuole and use a panel of tricks to exploit or evade eukaryotic cell functions ([9][1],[12][2]). Chlamydia inhabitsExpand
  • 106
  • 10
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The catalytic, glycosyl transferase and acyl transferase modules of the cell wall peptidoglycan‐polymerizing penicillin‐binding protein 1b of Escherichia coli
The penicillin‐binding protein (PBP) 1b of Escherichia coli catalyses the assembly of lipid‐transported N‐acetylExpand
  • 154
  • 8
  • PDF
Molecular structures of penicillin-binding proteins and β-lactamases
Abstract In the past, new antibacterial agents have been selected either from natural sources or by `trial and error' modification of existing antibacterials. Future therapeutic strategies are likelyExpand
  • 159
  • 6
Modular design of the Enterococcus hirae muramidase-2 and Streptococcus faecalis autolysin.
The mature forms of the extracellular muramidase-2 of Enterococcus hirae and Streptococcus faecalis autolysin have very similar primary structures. Each consists of an active-site-containingExpand
  • 155
  • 6
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