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Botanical drugs, synergy, and network pharmacology: forth and back to intelligent mixtures.
For centuries the science of pharmacognosy has dominated rational drug development until it was gradually substituted by target-based drug discovery in the last fifty years. Pharmacognosy stems fromExpand
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Alkylamides from Echinacea Are a New Class of Cannabinomimetics
Alkylamides (alkamides) from Echinacea modulate tumor necrosis factor α mRNA expression in human monocytes/macrophages via the cannabinoid type 2 (CB2) receptor (Gertsch, J., Schoop, R., Kuenzle, U.,Expand
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Identification and Quantification of a New Family of Peptide Endocannabinoids (Pepcans) Showing Negative Allosteric Modulation at CB1 Receptors*
Background: The α-hemoglobin-derived peptide RVDPVNFKLLSH was found to interact with cannabinoid CB1 receptors. Results: We generated mAbs against RVDPVNFKLLSH and identified a new family ofExpand
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The major central endocannabinoid directly acts at GABAA receptors
GABAA receptors are the major ionotropic inhibitory neurotransmitter receptors. The endocannabinoid system is a lipid signaling network that modulates different brain functions. Here we show a directExpand
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Evidence for Bidirectional Endocannabinoid Transport across Cell Membranes*
Background: The transport of endocannabinoids across cell membranes is poorly understood. Results: Using a new methodology, we provide experimental evidence for the bidirectional cell membraneExpand
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β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner.
(E)-β-caryophyllene (BCP) is a natural sesquiterpene found in many essential oils of spice (best known for contributing to the spiciness of black pepper) and food plants with recognizedExpand
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Endocannabinoid transport revisited.
Endocannabinoids are arachidonic acid-derived endogenous lipids that activate the endocannabinoid system which plays a major role in health and disease. The primary endocannabinoids are anandamideExpand
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Characteristics of the Calcium‐Triggered Mitochondrial Permeability Transition in Nonsynaptic Brain Mitochondria
Abstract: The objective of the present study was to assess the capacity of nonsynaptic brain mitochondria to accumulate Ca2+ when subjected to repeated Ca2+ loads, and to explore under whatExpand
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Synergistic immunomopharmacological effects of N-alkylamides in Echinacea purpurea herbal extracts.
Echinacea purpurea extracts are used in the production of standardized herbal medicines for the prevention and treatment of upper respiratory infections. Unsaturated N-alkylamide lipids, the mainExpand
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Cytochrome P450 inhibitory action of Echinacea preparations differs widely and co‐varies with alkylamide content
Echinacea preparations are one of the best selling herbal medicinal products with a well established therapeutic use in the prophylaxis of upper respiratory tract infections. Their consumption isExpand
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