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Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
BACKGROUND The chitinase-like protein YKL-40 is involved in inflammation and tissue remodeling. We recently showed that serum YKL-40 levels were elevated in patients with asthma and were correlatedExpand
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The Infant Nasopharyngeal Microbiome Impacts Severity of Lower Respiratory Infection and Risk of Asthma Development
Summary The nasopharynx (NP) is a reservoir for microbes associated with acute respiratory infections (ARIs). Lung inflammation resulting from ARIs during infancy is linked to asthmaExpand
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Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children.
RATIONALE Virus-induced wheezing episodes in infancy often precede the development of asthma. Whether infections with specific viral pathogens confer differential future asthma risk is incompletelyExpand
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Allele-specific targeting of microRNAs to HLA-G and risk of asthma.
HLA-G is a nonclassic, class I HLA molecule that has important immunomodulatory properties. Previously, we identified HLA-G as an asthma-susceptibility gene and discovered that the risk of asthma inExpand
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Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients With Wiskott-Aldrich Syndrome
A Aiuti, L Biasco, S Scaramuzza. Science. 2013;341(6148):1233151 The goal of this study was to develop a clinical protocol for Wiskott-Aldrich syndrome (WAS) by using a lentiviral vector (LV) toExpand
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Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children.
BACKGROUND Research has underscored the effects of exposure and sensitization to allergens on the severity of asthma in inner-city children. It has also revealed the limitations of environmentalExpand
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Chronic Mucocutaneous Candidiasis in Humans With Inborn Errors of Interleukin-17 Immunity
A Puel, S Cypowyj, J Bustamante. Science. 2011;332(6025):65–68 Chronic mucocutaneous candidiasis disease (CMCD) is characterized by recurrent or persistent infections of the skin, nails, and oralExpand
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A Diverse Group of Previously Unrecognized Human Rhinoviruses Are Common Causes of Respiratory Illnesses in Infants
Background Human rhinoviruses (HRVs) are the most prevalent human pathogens, and consist of 101 serotypes that are classified into groups A and B according to sequence variations. HRV infectionsExpand
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Rhinovirus illnesses during infancy predict subsequent childhood wheezing.
BACKGROUND The contribution of viral respiratory infections during infancy to the development of subsequent wheezing and/or allergic diseases in early childhood is not established. OBJECTIVE ToExpand
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Association between human rhinovirus C and severity of acute asthma in children
A new and potentially more pathogenic group of human rhinovirus (HRV), group C (HRVC), has recently been discovered. We hypothesised that HRVC would be present in children with acute asthma and causeExpand
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