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Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
BACKGROUND The chitinase-like protein YKL-40 is involved in inflammation and tissue remodeling. We recently showed that serum YKL-40 levels were elevated in patients with asthma and were correlated… Expand
The Infant Nasopharyngeal Microbiome Impacts Severity of Lower Respiratory Infection and Risk of Asthma Development
Summary The nasopharynx (NP) is a reservoir for microbes associated with acute respiratory infections (ARIs). Lung inflammation resulting from ARIs during infancy is linked to asthma… Expand
Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children.
- D. Jackson, R. Gangnon, +13 authors R. Lemanske
- American journal of respiratory and critical care…
- 1 October 2008
RATIONALE Virus-induced wheezing episodes in infancy often precede the development of asthma. Whether infections with specific viral pathogens confer differential future asthma risk is incompletely… Expand
Allele-specific targeting of microRNAs to HLA-G and risk of asthma.
- Z. Tan, G. Randall, +8 authors C. Ober
- Medicine, Biology
- American journal of human genetics
- 1 October 2007
HLA-G is a nonclassic, class I HLA molecule that has important immunomodulatory properties. Previously, we identified HLA-G as an asthma-susceptibility gene and discovered that the risk of asthma in… Expand
Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients With Wiskott-Aldrich Syndrome
A Aiuti, L Biasco, S Scaramuzza. Science. 2013;341(6148):1233151 The goal of this study was to develop a clinical protocol for Wiskott-Aldrich syndrome (WAS) by using a lentiviral vector (LV) to… Expand
Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children.
- W. Busse, W. Morgan, +14 authors C. Sorkness
- The New England journal of medicine
- 16 March 2011
BACKGROUND Research has underscored the effects of exposure and sensitization to allergens on the severity of asthma in inner-city children. It has also revealed the limitations of environmental… Expand
Chronic Mucocutaneous Candidiasis in Humans With Inborn Errors of Interleukin-17 Immunity
A Puel, S Cypowyj, J Bustamante. Science. 2011;332(6025):65–68 Chronic mucocutaneous candidiasis disease (CMCD) is characterized by recurrent or persistent infections of the skin, nails, and oral… Expand
A Diverse Group of Previously Unrecognized Human Rhinoviruses Are Common Causes of Respiratory Illnesses in Infants
Background Human rhinoviruses (HRVs) are the most prevalent human pathogens, and consist of 101 serotypes that are classified into groups A and B according to sequence variations. HRV infections… Expand
Rhinovirus illnesses during infancy predict subsequent childhood wheezing.
- R. Lemanske, D. Jackson, +14 authors J. Gern
- The Journal of allergy and clinical immunology
- 1 September 2005
BACKGROUND The contribution of viral respiratory infections during infancy to the development of subsequent wheezing and/or allergic diseases in early childhood is not established. OBJECTIVE To… Expand
Association between human rhinovirus C and severity of acute asthma in children
A new and potentially more pathogenic group of human rhinovirus (HRV), group C (HRVC), has recently been discovered. We hypothesised that HRVC would be present in children with acute asthma and cause… Expand