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Clinical extracorporeal hybrid liver support – phase I study with primary porcine liver cells
Abstract: The objective of this study was to evaluate the feasibility and safety of a hybrid liver support system with extracorporeal plasma separation and bioreactor perfusion in patients with acuteExpand
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HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro.
INTRODUCTION Primary human hepatocytes are considered as a highly predictive in vitro model for preclinical drug metabolism studies. Due to the limited availability of human liver tissue for cellExpand
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Porcine endogenous retroviruses: no infection in patients treated with a bioreactor based on porcine liver cells.
BACKGROUND Acute liver failure (ALF) remains a disease with high mortality. Bioartificial liver support systems, which combine living cells of the liver in an extracorporeal circuit, have beenExpand
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Scaling down of a clinical three-dimensional perfusion multicompartment hollow fiber liver bioreactor developed for extracorporeal liver support to an analytical scale device useful for hepatic
Within the scope of developing an in vitro culture model for pharmacological research on human liver functions, a three-dimensional multicompartment hollow fiber bioreactor proven to function as aExpand
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Bioartificial liver systems: why, what, whither?
Acute liver disease is a life-threatening condition for which liver transplantation is the only recognized effective therapy. While etiology varies considerably, the clinical course of acute liverExpand
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Analysis of drug metabolism activities in a miniaturized liver cell bioreactor for use in pharmacological studies
Based on a hollow fiber perfusion technology with internal oxygenation, a miniaturized bioreactor with a volume of 0.5 mL for in vitro studies was recently developed. Here, the suitability of thisExpand
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In vitro comparison of the molecular adsorbent recirculation system (MARS) and single‐pass albumin dialysis (SPAD)
The detoxification capacities of single‐pass albumin dialysis (SPAD), the molecular adsorbents recirculation system, (MARS) and continuous veno‐venous hemodiafiltration (CVVHDF) were compared inExpand
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Isolation and characterization of adult human liver progenitors from ischemic liver tissue derived from therapeutic hepatectomies.
Recent evidence suggests that progenitor cells in adult tissues and embryonic stem cells share a high resistance to hypoxia and ischemic stress. To study the ischemic resistance of adult liverExpand
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Extracorporeal liver support based on primary human liver cells and albumin dialysis--treatment of a patient with primary graft non-function.
METHODS Following liver transplantation, a 26-year old female suffered from primary non-function of the transplant. The patient was subsequently treated with a modular extracorporeal liver supportExpand
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Use of primary human liver cells originating from discarded grafts in a bioreactor for liver support therapy and the prospects of culturing adult liver stem cells in bioreactors: a morphologic study
Introduction. The development of a bioreactor providing a three-dimensional network of interwoven capillary membranes with integrated oxygenation and decentralized mass exchange enables the cultureExpand
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