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What is the Objective of the Mass Balance Study? A Retrospective Analysis of Data in Animal and Human Excretion Studies Employing Radiolabeled Drugs
TLDR
Overall, mean recovery was greater in rats and dogs than in humans, and absolute recovery in humans should not be used as a major decision criteria as to whether a radiolabeled study has met its objectives.
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Pharmacokinetics and metabolism of a selective PDE5 inhibitor (UK-343,664) in rat and dog
TLDR
UK-343,664 is a novel potent and selective PDE5 inhibitor that was in agreement with in vitro metabolism rates in hepatic microsomes and resulted in a longer elimination half-life in rat than dog.
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Pharmacokinetics and disposition of a novel NMDA glycine site antagonist (UK-240,455) in rats, dogs and man
TLDR
The species' variation in pharmacokinetic parameters was related allometrically when plasma protein binding was taken in to account, Hence, active hepatic or renal clearance processes for this compound were conserved across species.
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Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: A rationale for long-lived plasma radioactivity
TLDR
Data indicate that this metabolite results from the oxadiazole ring-cleavage-producing oxamic acid, oxamide and oxalic acid, and was identified as the long-lived radioactivity which was observed in dog plasma.
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A sensitive HPLC-MS-MS assay for quantitative determination of midazolam in dog plasma.
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