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- Publications
- Influence
What is the Objective of the Mass Balance Study? A Retrospective Analysis of Data in Animal and Human Excretion Studies Employing Radiolabeled Drugs
Mass balance excretion studies in laboratory animals and humans using radiolabeled compounds represent a standard part of the development process for new drugs. From these studies, the total fate of… Expand
A comparison of a low-dose warfarin induction regimen with the modified Fennerty regimen in elderly inpatients.
- J. Gedge, S. Orme, K. Hampton, K. Channer, T. J. Hendra
- Medicine
- Age and ageing
- 2000
OBJECTIVES
To compare a new low-dose warfarin induction regimen with the Fennerty regimen in elderly inpatients.
DESIGN
Age-stratified, randomized prospective study.
SUBJECTS
120 age-stratified… Expand
Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: A rationale for long-lived plasma radioactivity
- G. Allan, J. Gedge, A. Nedderman, S. Roffey, H. Small, R. Webster
- Chemistry, Medicine
- Xenobiotica; the fate of foreign compounds in…
- 1 May 2006
UK-383,367 (5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl}-1,2,4-oxadiazole-3-carboxamide) is a novel procollagen C-proteinase inhibitor evaluated for the treatment of post-surgical… Expand
Pharmacokinetics and disposition of a novel NMDA glycine site antagonist (UK-240,455) in rats, dogs and man
- R. Webster, S. Cole, J. Gedge, S. Roffey, Dee Walker, W. Wild
- Chemistry, Medicine
- Xenobiotica; the fate of foreign compounds in…
- 1 January 2003
1. UK-240,455 ((+) 6,7-dichloro-5-{ N- (2-hydroxyethyl)methanesulphonamido}-2,3 (1H,4H)-quinoxalinedione) is a potent, selective N- methyl D-aspartate (NMDA) glycine site antagonist that is being… Expand
Pharmacokinetics and metabolism of a selective PDE5 inhibitor (UK-343,664) in rat and dog
- D. Walker, K. Beaumont, +5 authors P. Wright
- Biology, Medicine
- Xenobiotica; the fate of foreign compounds in…
- 1 January 2001
1. UK-343,664 is a novel potent and selective PDE5 inhibitor. Plasma clearances in the male and female rat were high (120 and 54 ml min-1 kg-1), giving rise to short elimination half-lives (0.2 and… Expand
A sensitive HPLC-MS-MS assay for quantitative determination of midazolam in dog plasma.
- S. Harris, J. Gedge, A. Nedderman, S. Roffey, M. Savage
- Chemistry, Medicine
- Journal of pharmaceutical and biomedical analysis
- 1 April 2004
The clinical pharmacokinetics of midazolam have been extensively studied, due to its high clearance by CYP3A4 and sensitivity to drug-drug interactions. In order to investigate the potential to model… Expand
Note on the Anatomical Development of the Ruminant Stomach.
- J. Gedge
- Biology, Medicine
- Journal of anatomy and physiology