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What is the Objective of the Mass Balance Study? A Retrospective Analysis of Data in Animal and Human Excretion Studies Employing Radiolabeled Drugs
Mass balance excretion studies in laboratory animals and humans using radiolabeled compounds represent a standard part of the development process for new drugs. From these studies, the total fate ofExpand
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A comparison of a low-dose warfarin induction regimen with the modified Fennerty regimen in elderly inpatients.
OBJECTIVES To compare a new low-dose warfarin induction regimen with the Fennerty regimen in elderly inpatients. DESIGN Age-stratified, randomized prospective study. SUBJECTS 120 age-stratifiedExpand
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Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: A rationale for long-lived plasma radioactivity
UK-383,367 (5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl}-1,2,4-oxadiazole-3-carboxamide) is a novel procollagen C-proteinase inhibitor evaluated for the treatment of post-surgicalExpand
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Pharmacokinetics and disposition of a novel NMDA glycine site antagonist (UK-240,455) in rats, dogs and man
1. UK-240,455 ((+) 6,7-dichloro-5-{ N- (2-hydroxyethyl)methanesulphonamido}-2,3 (1H,4H)-quinoxalinedione) is a potent, selective N- methyl D-aspartate (NMDA) glycine site antagonist that is beingExpand
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Pharmacokinetics and metabolism of a selective PDE5 inhibitor (UK-343,664) in rat and dog
1. UK-343,664 is a novel potent and selective PDE5 inhibitor. Plasma clearances in the male and female rat were high (120 and 54 ml min-1 kg-1), giving rise to short elimination half-lives (0.2 andExpand
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A sensitive HPLC-MS-MS assay for quantitative determination of midazolam in dog plasma.
The clinical pharmacokinetics of midazolam have been extensively studied, due to its high clearance by CYP3A4 and sensitivity to drug-drug interactions. In order to investigate the potential to modelExpand
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Note on the Anatomical Development of the Ruminant Stomach.
  • J. Gedge
  • Biology, Medicine
  • Journal of anatomy and physiology
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