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What is a randomised controlled trial?
TLDR
The Consolidated Statement of Reporting Trials (CONSORT) provides readers of RCTs with a list of criteria useful to assess trial validity (for full details visit www.consortstatement.org). Expand
Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis
TLDR
A Bayesian-framework, multiple-treatments meta-analysis of randomised controlled trials to compare 15 antipsychotic drugs and placebo in the acute treatment of schizophrenia found all drugs were significantly more effective than placebo. Expand
Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis
TLDR
Clinically important differences exist between commonly prescribed antidepressants for both efficacy and acceptability in favour of escitalopram and sertraline, which might be the best choice when starting treatment for moderate to severe major depression in adults. Expand
Schizophrenia and Violence: Systematic Review and Meta-Analysis
TLDR
It is shown that the increased risk of schizophrenia and other psychoses and violence and violent offending appears to be partly mediated by substance abuse comorbidity. Expand
Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis
TLDR
This work aimed to update and expand previous work to compare and rank antidepressants for the acute treatment of adults with unipolar major depressive disorder, and found that all antidepressants were more effective than placebo. Expand
The health of homeless people in high-income countries: descriptive epidemiology, health consequences, and clinical and policy recommendations
TLDR
Recommendations to improve the surveillance of morbidity and mortality in homeless people are discussed, including programmes focused on high-risk groups, such as individuals leaving prisons, psychiatric hospitals and the child welfare system, and the introduction of national and state-wide plans that target homeless people. Expand
Introduction to Systematic Reviews
TLDR
The advantages, as the authors see them, of systematic over narrative methodology are reprise here the advantages of systematic in approach. Expand
Meta-analysis, database, and meta-regression of 98 structural imaging studies in bipolar disorder.
TLDR
The meta-analyses revealed robust but regionally nonspecific changes of brain structure in bipolar disorder and revealed individual studies will remain underpowered unless sample size is increased or improvements in phenotypic selection and imaging methods are made to reduce within-study heterogeneity. Expand
Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review
TLDR
Continuing treatment with antidepressants in patients with depressive disorders who have responded to acute treatment reduced the odds of relapse by 70% and seemed to persist for up to 36 months, although most trials were of 12 months' duration, and so the evidence on longer-term treatment requires confirmation. Expand
Atypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysis
TLDR
There is no clear evidence that atypical antipsychotics are more effective or are better tolerated than conventional antipsychotic drugs. Expand
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