J. Gea

Publications178
h-index30
Citations3,458
Highly Influential Citations134
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Oxidative stress and respiratory muscle dysfunction in severe chronic obstructive pulmonary disease.
RATIONALE Oxidative stress is involved in the skeletal muscle dysfunction observed in patients with severe chronic obstructive pulmonary disease (COPD). We hypothesized that the diaphragms of such… Expand
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Cigarette smoke-induced oxidative stress: A role in chronic obstructive pulmonary disease skeletal muscle dysfunction.
RATIONALE Inflammation and oxidative stress contribute to muscle dysfunction in patients with chronic obstructive pulmonary disease (COPD). Oxidants contained in cigarette smoke (CS) induce adverse… Expand
  • 205
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Injury of the human diaphragm associated with exertion and chronic obstructive pulmonary disease.
Injury of the diaphragm may have clinical relevance having been reported in cases of sudden infant death syndrome or fatal asthma. However, examination of diaphragm injury after acute inspiratory… Expand
  • 195
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Pathophysiology of muscle dysfunction in COPD.
Muscle dysfunction often occurs in patients with chronic obstructive pulmonary disease (COPD) and may involve both respiratory and locomotor (peripheral) muscles. The loss of strength and/or… Expand
  • 117
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Muscle dysfunction in chronic obstructive pulmonary disease: update on causes and biological findings.
Respiratory and/or limb muscle dysfunction, which are frequently observed in chronic obstructive pulmonary disease (COPD) patients, contribute to their disease prognosis irrespective of the lung… Expand
  • 73
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Early diagnosis of acute myocardial infarction in the elderly using more sensitive cardiac troponin assays.
AIMS To examine the diagnostic accuracy of sensitive cardiac troponin (cTn) assays in elderly patients, since elevated levels with sensitive cTn assays were reported in 20% of elderly patients… Expand
  • 241
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Rapid rule out of acute myocardial infarction using undetectable levels of high-sensitivity cardiac troponin.
BACKGROUND We examined whether undetectable levels of high-sensitivity cardiac Troponin (hs-cTn) can be used to rule out acute myocardial infarction (AMI) with a single blood draw at presentation to… Expand
  • 163
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Oxidative stress, redox signaling pathways, and autophagy in cachectic muscles of male patients with advanced COPD and lung cancer.
Muscle dysfunction and wasting are predictors of mortality in advanced COPD and malignancies. Redox imbalance and enhanced protein catabolism are underlying mechanisms in COPD. We hypothesized that… Expand
  • 87
  • 5
Subcellular adaptation of the human diaphragm in chronic obstructive pulmonary disease.
Pulmonary hyperinflation impairs the function of the diaphragm in patients with chronic obstructive pulmonary disease (COPD). However, it has been recently demonstrated that the muscle can… Expand
  • 213
  • 4
Guidelines for the evaluation and treatment of muscle dysfunction in patients with chronic obstructive pulmonary disease.
In patients with chronic obstructive pulmonary disease (COPD), skeletal muscle dysfunction is a major comorbidity that negatively impacts their exercise capacity and quality of life. In the current… Expand
  • 29
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