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Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT).
TLDR
Selenium or vitamin E, alone or in combination at the doses and formulations used, did not prevent prostate cancer in this population of relatively healthy men.
Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease.
TLDR
In this trial among healthy men, 12 years of supplementation with beta carotene produced neither benefit nor harm in terms of the incidence of malignant neoplasms, cardiovascular disease, or death from all causes.
A Randomized Trial of Low-Dose Aspirin in the Primary Prevention of Cardiovascular Disease in Women
TLDR
Subgroup analyses showed that aspirin significantly reduced the risk of major cardiovascular events, ischemic stroke, and myocardial infarction among women 65 years of age or older, leading to a nonsignificant finding with respect to the primary end point.
Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction.
TLDR
The inverse association of moderate alcohol intake with the risk of myocardial infarction is confirmed and support the view that the effect is mediated, in large part, by increases in both HDL2 and HDL3.
Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community.
TLDR
Higher serum phosphorus levels are associated with an increased CVD risk in individuals free of CKD and CVD in the community and the need for additional research to elucidate the potential link between phosphorus homeostasis and vascular risk is emphasized.
Results of multivariable logistic regression, propensity matching, propensity adjustment, and propensity-based weighting under conditions of nonuniform effect.
Observational studies often provide the only available information about treatment effects. Control of confounding, however, remains challenging. The authors compared five methods for evaluating the
Soft Drink Consumption and Risk of Developing Cardiometabolic Risk Factors and the Metabolic Syndrome in Middle-Aged Adults in the Community
TLDR
In middle-aged adults, soft drink consumption is associated with a higher prevalence and incidence of multiple metabolic risk factors.
A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study.
TLDR
There were no overall effects of ascorbic acid, vitamin E, or beta carotene on cardiovascular events among women at high risk for CVD.
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
TLDR
The largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry identifies 535 novel blood pressure loci that offer new insights into blood pressure regulation.
Sex hormone-binding globulin and risk of type 2 diabetes in women and men.
TLDR
Low circulating levels of sex hormone-binding globulin are a strong predictor of the risk of type 2 diabetes in women and men and may have a causal role in the risk in men.
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