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Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer.
The murine Pten prostate cancer model described in this study recapitulates the disease progression seen in humans: initiation of prostate cancer with prostatic intraepithelial neoplasia (PIN),… Expand
Penetration and distribution of PLGA nanoparticles in the human skin treated with microneedles.
- W. Zhang, J. Gao, +9 authors S. Gao
- Chemistry, Medicine
- International journal of pharmaceutics
- 15 December 2010
This study was designed to investigate the penetration and the distribution of poly(d,l-lactic-co-glycolic acid) (PLGA) nanoparticles in the human skin treated with microneedles. Fluorescent… Expand
NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss.
We demonstrate that PTEN loss causes reduced NKX3.1 expression in both murine and human prostate cancers. Restoration of Nkx3.1 expression in vivo in Pten null epithelium leads to decreased cell… Expand
Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism
- J. Gao, Kang Xu, +5 authors Yulong Yin
- Medicine, Biology
- Front. Cell. Infect. Microbiol.
- 6 February 2018
The gut microbiota influences the health of the host, especially with regard to gut immune homeostasis and the intestinal immune response. In addition to serving as a nutrient enhancer, L-tryptophan… Expand
Carbonic anhydrase IV inhibits colon cancer development by inhibiting the Wnt signalling pathway through targeting the WTAP–WT1–TBL1 axis
Objective We found that carbonic anhydrase IV (CA4), a member of the carbonic anhydrases, is silenced in colorectal cancer (CRC). We analysed its epigenetic inactivation, biological effects and… Expand
Osteocalcin Induces Release of Glucagon-Like Peptide-1 and Thereby Stimulates Insulin Secretion in Mice
The uncarboxylated form (ucOC), but not the γ-carboxylated form (GlaOC), of the bone-derived protein osteocalcin stimulates insulin secretion and regulates energy metabolism in insulin target… Expand
Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells
- Min-fang Xu, Yu-yun Xiong, J. Liu, Jin-jun Qian, L. Zhu, J. Gao
- Biology, Medicine
- Acta Pharmacologica Sinica
- 26 March 2012
Aim:To investigate whether asiatic acid (AA), a pentacyclic triterpene in Centella asiatica, exerted neuroprotective effects in vitro and in vivo, and to determine the underlying… Expand
Laminin‐10 is crucial for hair morphogenesis
The role of the extracellular matrix in cutaneous morphogenesis is poorly understood. Here, we describe the essential role of laminin‐10 (α5β1γ1) in hair follicle development. Laminin‐10 was present… Expand
Protein Inhibitor of Activated STAT Y (PIASy) and a Splice Variant Lacking Exon 6 Enhance Sumoylation but Are Not Essential for Embryogenesis and Adult Life
- Kelly A. Wong, R. Kim, H. Christofk, J. Gao, G. Lawson, H. Wu
- Medicine, Biology
- Molecular and Cellular Biology
- 15 June 2004
ABSTRACT Protein inhibitor of activated STAT Y (PIASy) is the shortest member of the PIAS family and has been reported to modulate the transcriptional activities of STAT1, lymphoid enhancer factor 1… Expand
Disruption of Nectin-Like 1 Cell Adhesion Molecule Leads to Delayed Axonal Myelination in the CNS
Nectin-like 1 (Necl-1) is a neural-specific cell adhesion molecule that is expressed in both the CNS and PNS. Previous in vitro studies suggested that Necl-1 expression is essential for the… Expand