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Classification of amyloidosis by laser microdissection and mass spectrometry-based proteomic analysis in clinical biopsy specimens.
TLDR
The development of a highly specific and sensitive novel test for the typing of amyloidosis in routine clinical biopsy specimens that combines specific sampling by laser microdissection (LMD) and analytical power of tandem mass spectrometry (MS)-based proteomic analysis. Expand
Direct Comparison of Demyelinating Disease Induced by the Daniel's Strain and BeAn Strain of Theiler's Murine Encephalomyelitis Virus
TLDR
Findings indicate that the diseases induced by DA or BeAn are distinct, and functional deficits as measured by Rotarod were more severe in DA infected versus BeAn infected mice. Expand
Gamma Interferon Is Critical for Neuronal Viral Clearance and Protection in a Susceptible Mouse Strain following Early Intracranial Theiler's Murine Encephalomyelitis Virus Infection
TLDR
In vitro analysis of virus-induced death in NSC34 cells and spinal motor neurons showed that IFN-γ exerted a neuroprotective effect in the absence of other aspects of the immune response, supporting the hypothesis that IFn-γ plays a critical role in protecting spinal cord neurons from persistent infection and death. Expand
In vivo magnetic resonance imaging of immune cells in the central nervous system with superparamagnetic antibodies
TLDR
A novel MRI technique to image immune cell location and homing in vivo to the central nervous system (CNS) of mice infected with Theiler's murine encephalomyelitis virus and in mice with experimental autoimmune encephalomeelitis (EAE). Expand
Glomeruli of Dense Deposit Disease contain components of the alternative and terminal complement pathway.
TLDR
This study shows that in addition to fluid-phase dysregulation of the alternative pathway, soluble components of the terminal complement complex contribute to glomerular lesions found in DDD. Expand
Magnetic resonance imaging of immune cells in inflammation of central nervous system.
TLDR
MRM with targeted contrast materials can be used to localize CNS-infiltrating lymphocytes of interest and due to its noninvasive character, could potentially be used in human MR imaging as well. Expand
Immunoglobulin derived depositions in the nervous system: novel mass spectrometry application for protein characterization in formalin-fixed tissues
TLDR
It is shown that proteinaceous deposits in the nervous system contain immunoglobulin components and liquid chromatography–electrospray tandem mass spectrometry accurately identifies the content of these deposits in clinical biopsy specimens. Expand
Mass spectrometry-based proteomic diagnosis of renal immunoglobulin heavy chain amyloidosis.
TLDR
It is concluded that LMD/MS is a sensitive and specific tool for diagnosis and accurate typing of renal amyloidosis, including Ig heavy chain amyloids. Expand
CD33 detection by immunohistochemistry in paraffin-embedded tissues: a new antibody shows excellent specificity and sensitivity for cells of myelomonocytic lineage.
TLDR
In cases of acute leukemia, the CD33 antibody showed equivalent results by immunohistochemical analysis compared with flow cytometric analysis and was found to be a useful marker in the workup of acute leukemias and myeloid sarcomas on paraffin-embedded tissue samples. Expand
A human antibody that promotes remyelination enters the CNS and decreases lesion load as detected by T2‐weighted spinal cord MRI in a virus‐induced murine model of MS
TLDR
A significant decrease was seen in T2 high signal lesion volume following antibody treatment, and this may be considered as additional evidence to the hypothesis that rHIgM22 promotes remyelination by local effects in the lesions, likely by binding to CNS cells. Expand
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