• Publications
  • Influence
Cajal bodies: the first 100 years.
  • J. Gall
  • Biology
    Annual review of cell and developmental biology
  • 2000
TLDR
A model is discussed in which Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA in eukaryotic RNA polymerases and factors required for transcribing and processing their respective nuclear transcripts.
A conserved double-stranded RNA-binding domain.
TLDR
On the basis of the binding studies and computer analysis, a consensus sequence is derived that defines a 65- to 68-amino acid dsRNA-binding domain, the minimal region that binds ds RNA.
Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases
TLDR
The application of the ZFN injection procedure to mutagenesis by NHEJ of 2 new genes in Drosophila melanogaster is described and pairs of novel ZFNs designed for targets within those genes led to the production of null mutations at each locus.
Assembly of the nuclear transcription and processing machinery: Cajal bodies (coiled bodies) and transcriptosomes.
TLDR
A model is presented in which pol I, pol II, and pol III transcriptosomes are assembled in the Cajal bodies before export to the nucleolus, to the B-snurposomes and eventually to the chromosomes (pol II), and directly to the chromosome (pol III).
The Cajal body and histone locus body.
TLDR
The Cajal body (CB) is a nuclear organelle present in all eukaryotes that have been carefully studied, and the histone locus body (HLB) contains factors required for processing histone pre-mRNAs.
The Drosophila melanogaster Cajal body
TLDR
The identification of these nuclear bodies in D. melanogaster permits a broad range of questions to be asked about CB structure and function in a genetically tractable organism.
Chromosomal Localization of Mouse Satellite DNA
Hybridization of radioactive nucleic acids with the DNA of cytological preparations shows that the sequences of mouse satellite DNA are located in the centromeric heterochromatin of the mouse
Formation and detection of RNA-DNA hybrid molecules in cytological preparations.
  • J. Gall, M. Pardue
  • Biology
    Proceedings of the National Academy of Sciences…
  • 1 June 1969
TLDR
A technique is described for forming molecular hybrids between RNA in solution and the DNA of intact cytological preparations and a low level of gene amplification was also detected in premeiotic nuclei (oogonia) of the toad Xenopus.
The centennial of the Cajal body
  • J. Gall
  • Biology
    Nature Reviews Molecular Cell Biology
  • 1 December 2003
Exactly 100 years ago, the Spanish neurobiologist Santiago Ramón y Cajal described a new organelle in the nuclei of vertebrate neurons. Now called the Cajal body, this organelle occurs in many cell
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