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Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain
Microglia actively survey the brain microenvironment and play essential roles in sculpting synaptic connections during brain development. While microglial functions in the adult brain are less clear,Expand
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Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex.
Epileptic cortex is characterized by paroxysmal electrical discharges. Analysis of these interictal discharges typically manifests as spike-wave complexes on electroencephalography, and plays aExpand
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From symphony to cacophony: Pathophysiology of the human basal ganglia in Parkinson disease
Despite remarkable advances, the relationship between abnormal neuronal activity and the clinical manifestations of Parkinson disease (PD) remains unclear. Numerous hypotheses have emerged to explainExpand
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Microscopic magnetic stimulation of neural tissue
Electrical stimulation is currently used to treat a wide range of cardiovascular, sensory and neurological diseases. Despite its success, there are significant limitations to its application,Expand
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Mechanisms of action of deep brain stimulation (DBS)
Deep brain stimulation (DBS) is remarkably effective for a range of neurological and psychiatric disorders that have failed pharmacological and cell transplant therapies. Clinical investigations areExpand
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Microelectrode-Guided Deep Brain Stimulation for Tourette Syndrome: Within-Subject Comparison of Different Stimulation Sites
Background: As medical therapy for Tourette syndrome (TS) is ineffective in a small subset of patients, surgical interventions, including deep brain stimulation at various sites, have been developedExpand
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OBJECTIVEHemorrhage is an infrequent but potentially devastating complication of deep brain stimulation (DBS) surgery. We examined the factors associated with hemorrhage after DBS surgery andExpand
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Single-Neuron Responses in the Human Nucleus Accumbens during a Financial Decision-Making Task
Linking values to actions and evaluating expectations relative to outcomes are both central to reinforcement learning and are thought to underlie financial decision-making. However, neurophysiologyExpand
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Action Initiation in the Human Dorsal Anterior Cingulate Cortex
The dorsal anterior cingulate cortex (dACC) has previously been implicated in processes that influence action initiation. In humans however, there has been little direct evidence connecting dACC toExpand
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Chronic Deep Cerebellar Stimulation Promotes Long-Term Potentiation, Microstructural Plasticity, and Reorganization of Perilesional Cortical Representation in a Rodent Model
Control over postinjury CNS plasticity is a major frontier of science that, if conquered, would open new avenues for treatment of neurological disorders. Here we investigate the functional,Expand
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