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Initial sequencing and analysis of the human genome.
The results of an international collaboration to produce and make freely available a draft sequence of the human genome are reported and an initial analysis is presented, describing some of the insights that can be gleaned from the sequence.
The genome sequence of the filamentous fungus Neurospora crassa
A high-quality draft sequence of the N. crassa genome is reported, suggesting that RIP has had a profound impact on genome evolution, greatly slowing the creation of new genes through genomic duplication and resulting in a genome with an unusually low proportion of closely related genes.
Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium
Comparison of genomes of three phenotypically diverse Fusarium species revealed lineage-specific genomic regions in F. oxysporum that include four entire chromosomes and account for more than one-quarter of the genome, putting the evolution of fungal pathogenicity into a new perspective.
The genome sequence of the rice blast fungus Magnaporthe grisea
The draft sequence of the M. grisea genome is reported, reflecting the clonal nature of this fungus imposed by widespread rice cultivation and analysis of the gene set provides an insight into the adaptations required by a fungus to cause disease.
Genome Sequence of Aedes aegypti, a Major Arbovirus Vector
An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An.
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus and revealed temperature-dependent expression of distinct sets of genes, as well as 700 A. fumigatus genes not present or significantly diverged in the closely related sexual species Neosartorya fischeri, many of which may have roles in the pathogenicity phenotype.
Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis
The discovery of the secreted protein gene clusters and the functional demonstration of their decisive role in the infection process illuminate previously unknown mechanisms of pathogenicity operating in biotrophic fungi.
Lessons from the Genome Sequence of Neurospora crassa: Tracing the Path from Genomic Blueprint to Multicellular Organism
An analysis of over 1,100 of the ∼10,000 predicted proteins encoded by the genome sequence of the filamentous fungus Neurospora crassa reveals potential new targets for antifungals as well as loci implicated in human and plant physiology and disease.
Dynamics of Pseudomonas aeruginosa genome evolution
- K. Mathee, G. Narasimhan, S. Lory
- BiologyProceedings of the National Academy of Sciences
- 26 February 2008
The complete sequence and comparative analysis of the genomes of two representative P. aeruginosa strains isolated from cystic fibrosis patients whose genetic disorder predisposes them to infections by this pathogen suggest that niche adaptation is a major evolutionary force influencing the composition of bacterial genomes.
Genome sequencing and analysis of Aspergillus oryzae
Specific expansion of genes for secretory hydrolytic enzymes, amino acid metabolism and amino acid/sugar uptake transporters supports the idea that A. oryzae is an ideal microorganism for fermentation.