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GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations.
TLDR
It is suggested that an evolutionary preserved role for excitatory GABA in immature cells provides an important mechanism in the formation of synapses and activity in neuronal networks. Expand
Giant synaptic potentials in immature rat CA3 hippocampal neurones.
TLDR
In neurones in which evoked GDPs were blocked by bicuculline, a NMDA‐mediated component was revealed by increasing the strength or the frequency of stimulation, and during the second week of postnatal life, superfusion with bicuciulline induced, as in adult slices, interictal discharges. Expand
GABAA, NMDA and AMPA receptors: a developmentally regulated `ménage à trois'
TLDR
Determining the mechanisms underlying the development of this 'ménage à trois' will shed light not only on the wide range of trophic roles of glutamate and GABA in the developing brain, but also on the significance of the transition from neonatal to adult forms of plasticity. Expand
GABA: an excitatory transmitter in early postnatal life
TLDR
In the adult mammalian CNS, GABA is the main inhibitory transmitter, and during the early neonatal period, GABA acting on GABAA receptors provides most of the excite drive, whereas excitatory glutamatergic synapses are quiescent. Expand
Synchronization of GABAergic interneuronal network in CA3 subfield of neonatal rat hippocampal slices.
TLDR
It is concluded that synchronous activation of SR‐CA3 interneurons during generation of GDPs is mediated synaptically and is determined by the co‐operation of excitatory GABAergic connections between interneerons and glutamatergic connections to interneURons originating presumably from the pyramidal cells. Expand
Long-term plasticity at GABAergic and glycinergic synapses: mechanisms and functional significance
TLDR
Different forms of plasticity at GABAergic, and the closely related glycinergic, synapses have been reported in several regions of the brain and their possible roles in developing and adult neuronal networks are reviewed. Expand
Bidirectional plasticity expressed by GABAergic synapses in the neonatal rat hippocampus.
TLDR
Early in development, bidirectional synaptic plasticity is expressed by GABAA receptors and the activation (or not) of NMDA receptors determines the induction of either LTPGABAA or LTDGABAA. Expand
Backpropagating Action Potentials Trigger Dendritic Release of BDNF during Spontaneous Network Activity
TLDR
The hypothesis that BDNF might act as a target-derived messenger of activity-dependent synaptic plasticity and development is supported by evidence that endogenous BDNF released from a single neuron can phosphorylate CREB in neighboring neurons. Expand
Spontaneous release of GABA activates GABAB receptors and controls network activity in the neonatal rat hippocampus.
TLDR
The results suggest that in the neonatal CA3 hippocampal region, spontaneously released GABA reaches a critical level and activates GABAB receptors on both pyramidal cells and interneurons thus regulating the level of glutamatergic and GABAergic activity in the CA3 neuronal network. Expand
GABA is the principal fast-acting excitatory transmitter in the neonatal brain.
TLDR
GDPs provide synchronous intracellular Ca2+ oscillations and may be implicated in hebbian modulation of developing synapses and activity-dependent formation of the hippocampal network and they are mediated by the synergistic excitatory actions of GABAA and glutamate receptors. Expand
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