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- Publications
- Influence
Hyaluronan-mediated angiogenesis in vascular disease: uncovering RHAMM and CD44 receptor signaling pathways.
- M. Slevin, J. Krupiński, +5 authors S. Kumar
- Biology, Medicine
- Matrix biology : journal of the International…
- 2007
The correct formation of new blood vessels from existing vasculature (angiogenesis) is essential for embryogenesis and the effective repair of damaged or wounded tissues. However, excessive and… Expand
Serial measurement of vascular endothelial growth factor and transforming growth factor-beta1 in serum of patients with acute ischemic stroke.
- M. Slevin, J. Krupiński, A. Słowik, P. Kumar, A. Szczudlik, J. Gaffney
- Medicine
- Stroke
- 1 August 2000
BACKGROUND AND PURPOSE
Both vascular endothelial growth factor (VEGF) and transforming growth factor-beta1 (TGF-beta1) are expressed in higher than normal concentrations in the penumbra of patients… Expand
Oligosaccharides of hyaluronan induce angiogenesis through distinct CD44 and RHAMM-mediated signalling pathways involving Cdc2 and gamma-adducin.
- S. Matou-Nasri, J. Gaffney, S. Kumar, M. Slevin
- Biology, Medicine
- International journal of oncology
- 1 October 2009
We used short-interfering RNA (siRNA) to knockdown the hyaluronan (HA) receptors CD44 and the receptor for hyaluronan-mediated motility (RHAMM) in vascular endothelial cells to investigate their role… Expand
Angiogenic Oligosaccharides of Hyaluronan Induce Multiple Signaling Pathways Affecting Vascular Endothelial Cell Mitogenic and Wound Healing Responses*
- M. Slevin, S. Kumar, J. Gaffney
- Biology, Medicine
- The Journal of Biological Chemistry
- 25 October 2002
Hyaluronan (HA) is a large nonsulfated glycosaminoglycan and an important regulator of angiogenesis, in particular, the growth and migration of vascular endothelial cells. We have identified some of… Expand
Angiogenic oligosaccharides of hyaluronan induce protein tyrosine kinase activity in endothelial cells and activate a cytoplasmic signal transduction pathway resulting in proliferation.
- M. Slevin, J. Krupiński, S. Kumar, J. Gaffney
- Biology, Medicine
- Laboratory investigation; a journal of technical…
- 1 August 1998
We have recently shown that the degradation products of hyaluronan of 3 to 10 disaccharides (o-HA), but not native high molecular weight hyaluronan, can induce angiogenesis in vivo and, as such, o-HA… Expand
Changes in hyaluronan production and metabolism following ischaemic stroke in man.
- A. Al'Qteishat, J. Gaffney, +6 authors M. Slevin
- Medicine, Biology
- Brain : a journal of neurology
- 1 August 2006
The extent of recovery from stroke is dependent on the survival of neurons, particularly in peri-infarcted regions. Angiogenesis is critical for the development of new microvessels and leads to… Expand
A microarray study of gene and protein regulation in human and rat brain following middle cerebral artery occlusion
- Nick Mitsios, M. Saka, +9 authors M. Slevin
- Biology, Medicine
- BMC Neuroscience
- 12 November 2007
BackgroundAltered gene expression is an important feature of ischemic cerebral injury and affects proteins of many functional classes. We have used microarrays to investigate the changes in gene… Expand
Therapeutic applications of hyaluronan.
- J. Gaffney, Sabine Matou-Nasri, M. Grau-Olivares, M. Slevin
- Chemistry, Medicine
- Molecular bioSystems
- 17 February 2010
Hyaluronan (HA), a multifunctional, high molecular weight glycosaminoglycan, is a component of the majority of extracellular matrices. HA is synthesised in a unique manner by a family of hyaluronan… Expand
Differences in the uptake of modified low density lipoproteins by tissue cultured endothelial cells.
- J. Gaffney, D. West, F. Arnold, A. Sattar, S. Kumar
- Biology, Medicine
- Journal of cell science
- 1 November 1985
Acetylated low density lipoprotein (Ac-LDL) is taken up by bovine aortic and adrenal capillary cells but not by brain capillary cells. This indicates that the uptake of Ac-LDL is not a feature of all… Expand
Aminosalicylic acid reduces the antiproliferative effect of hyperglycaemia, advanced glycation endproducts and glycated basic fibroblast growth factor in cultured bovine aortic endothelial cells:…
- Y. Duraisamy, J. Gaffney, M. Slevin, C. A. Smith, Kenneth Williamson, N. Ahmed
- Medicine
- 1 April 2003
Hyperglycaemia reduces proliferation of bovine aortic endothelial cells in vitro. A similar effect in vivo may contribute to longterm complications of diabetes such as impaired wound-healing and… Expand
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