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Chimeric papillomavirus-like particles.
It is speculated that CVLPs can be used to deliver peptides into mammalian cells in vitro and in vivo, possibly reaching the pathway for MHC class I presentation.
Vaccination trial with HPV16 L1E7 chimeric virus‐like particles in women suffering from high grade cervical intraepithelial neoplasia (CIN 2/3)
Evidence for safety and a nonsignificant trend for the clinical efficacy of the HPV16 L1E7 CVLP vaccine is demonstrated.
Purification and characterization of a novel thermostable 4-alpha-glucanotransferase of Thermotoga maritima cloned in Escherichia coli.
- W. Liebl, R. Feil, J. Gabelsberger, J. Kellermann, K. Schleifer
- BiologyEuropean journal of biochemistry
- 1 July 1992
Comparison of the N-terminal amino acid sequence of 4-alpha-glucanotransferase with other published protein sequences revealed significant similarity to sequences near theN-termini of various eucaryotic maltases and bacterial cyclodextrin glycosyltransferases, suggesting its relatedness on the molecular level with other starch- and maltodextrine-converting enzymes.
Safety and Immunogenicity of a Pseudomonas aeruginosa Hybrid Outer Membrane Protein F-I Vaccine in Human Volunteers
The continued development of an OprF-OprI vaccine for use in humans and the capacity of the elicited antibodies to promote complement binding and opsonization could be demonstrated by a C1q-binding assay and by the in vitro opsonophagocytic uptake of P. aeruginosa bacteria.
Safety and immunogenicity of an intranasal Pseudomonas aeruginosa hybrid outer membrane protein F-I vaccine in human volunteers.
HPV16 L1E7 chimeric virus‐like particles induce specific HLA‐restricted T cells in humans after in vitro vaccination
The data conclude from the data that CVLP show promise for a therapeutic vaccine in patients with HPV16‐positive cervical intraepithelial neoplasia lesions or cervical cancer.
Cloning and characterization of β-galactoside and β-glucoside hydrolysing enzymes of Thermotoga maritima
A gene library of the hyperthermophilic bacterium Thermotoga maritima strain MSB8 was constructed in Escherichia coli and the biochemical properties of the recombinant enzymes indicated that genes for a β-galactosidase and a broad-specificity β-glucosid enzyme had been isolated.
Clinical study to assess the immunogenicity and safety of a recombinant Pseudomonas aeruginosa OprF-OprI vaccine in burn patients.
A recombinant hybrid outer membrane protein for vaccination against Pseudomonas aeruginosa.