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Clinical Pharmacokinetics and Pharmacodynamics of Immune Checkpoint Inhibitors
Immune checkpoint inhibitors (ICIs) have demonstrated significant clinical impact in improving overall survival of several malignancies associated with poor outcomes; however, only 20–40% of patientsExpand
Systematic Evaluation of the Descriptive and Predictive Performance of Paediatric Morphine Population Models
ABSTRACTPurposeA framework for the evaluation of paediatric population models is proposed and applied to two different paediatric population pharmacokinetic models for morphine. One covariate modelExpand
Novel Δ(9) -tetrahydrocannabinol formulation Namisol® has beneficial pharmacokinetics and promising pharmacodynamic effects.
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Cannabis based medicines are registered as a treatment for various indications, such as pain and spasms in multiple sclerosis (MS) patients, and anorexiaExpand
Population Pharmacokinetics of Vancomycin in Premature Malaysian Neonates: Identification of Predictors for Dosing Determination
ABSTRACT The present study determined the pharmacokinetic profile of vancomycin in premature Malaysian infants. A one-compartment infusion model with first-order elimination was fitted to serumExpand
Integrated semi-physiological pharmacokinetic model for both sunitinib and its active metabolite SU12662.
AIMS Previously published pharmacokinetic (PK) models for sunitinib and its active metabolite SU12662 were based on a limited dataset or lacked important elements such as correlations betweenExpand
Renal function, body surface area, and age are associated with risk of early-onset fluoropyrimidine-associated toxicity in patients treated with capecitabine-based anticancer regimens in daily
BACKGROUND The objective of this analysis was to determine the factors associated with early onset treatment-related toxicity in patients treated with capecitabine-based anticancer regimens in dailyExpand
Optimizing anticancer drug treatment in pregnant cancer patients: pharmacokinetic analysis of gestation-induced changes for doxorubicin, epirubicin, docetaxel and paclitaxel.
BACKGROUND Pregnant patients with cancer are increasingly treated with anticancer drugs, although the specific impact of pregnancy-induced physiological changes on the pharmacokinetics (PK) ofExpand
Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity
Nephrotoxicity is a critical adverse event that leads to discontinuation of kinase inhibitor (KI) treatment. Here we show, through meta-analyses of FDA Adverse Event Reporting System, that dasatinibExpand
A Review of Mathematical Models for Tumor Dynamics and Treatment Resistance Evolution of Solid Tumors
We comprehensively summarized mathematical models of tumor dynamics for solid tumors and of drug resistance evolution during treatment for patients with solid tumors. Expand
Host-response biomarkers for the diagnosis of bacterial respiratory tract infections
Abstract Appropriate antibiotic treatment for respiratory tract infections (RTIs) necessitates rapid and accurate diagnosis of microbial etiology, which remains challenging despite recentExpand