Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism.
- A. Köster, Y. Chao, P. Eacho
- 1 November 2005
Angptl3 and Angptl4 function to regulate circulating triglyceride levels during different nutritional states and therefore play a role in lipid metabolism during feeding/fasting through differential inhibition of LPL.
The Drosophila homeotic target gene centrosomin (cnn) encodes a novel centrosomal protein with leucine zippers and maps to a genomic region required for midgut morphogenesis.
- J. G. Heuer, K. Li, T. Kaufman
- 1 November 1995
Characterization of a cDNA encoding CNN predicts a novel structural protein with three leucine zipper motifs and several coiled-coil domains exhibiting limited homology to the rod portion of myosin, which may participate in mitotic spindle assembly and the mechanics of morphogenesis through an interaction with microtubules.
Structure and developmental expression of the chicken NGF receptor.
- J. G. Heuer, S. Fatemie-Nainie, E. Wheeler, M. Bothwell
- BiologyDevelopmental Biology
- 1 February 1990
Alternating phases of FGF receptor and NGF receptor expression in the developing chicken nervous system
- J. G. Heuer, C. S. Bartheld, Y. Kinoshita, P. Evers, M. Bothwell
- 1 September 1990
Role of protein C in renal dysfunction after polymicrobial sepsis.
- Akanksha Gupta, D. T. Berg, B. Grinnell
- Biology, MedicineJournal of the American Society of Nephrology
- 1 March 2007
It is shown that a rapid drop in PC after sepsis is strongly associated with an increase in blood urea nitrogen, renal pathology, and expression of known markers of renal injury, including neutrophil gelatinase-associated lipocalin, CXCL1, andCXCL2.
Adoptive Transfer of In Vitro-Stimulated CD4+CD25+ Regulatory T Cells Increases Bacterial Clearance and Improves Survival in Polymicrobial Sepsis
- J. G. Heuer, Tonghai Zhang, S. Na
- Biology, MedicineJournal of Immunology
- 1 June 2005
Adoptive transfer of in vitro-stimulated Tregs in both prevention and therapeutic modes significantly improved survival of cecal ligation and puncture mice and suggest a novel role for T Regs in sepsis.
FGF21 is increased by inflammatory stimuli and protects leptin-deficient ob/ob mice from the toxicity of sepsis.
- K. Feingold, C. Grunfeld, A. Kharitonenkov
- 2 April 2012
FGF21 is a positive APR protein that protects animals from the toxic effects of LPS and sepsis, and treatment with exogenous FGF21 reduced the number of animals that die and the rapidity of death after LPS administration in leptin-deficient ob/ob mice and to a lesser extent in control mice.
Expression of nerve growth factor (NGF) receptors in the developing inner ear of chick and rat.
- C. V. von Bartheld, S. Patterson, J. G. Heuer, E. Wheeler, M. Bothwell, E. Rubel
- 1 October 1991
Onset of NGFR mRNA expression in the acoustic ganglion during the period of afferent fiber ingrowth into the otocyst epithelium is consistent with the hypothesis that NGF-like molecules may have a neurotrophic function for acoustic ganglia cells.
Evaluation of protein C and other biomarkers as predictors of mortality in a rat cecal ligation and puncture model of sepsis*
- J. G. Heuer, Ganesh R. Sharma, J. Jakubowski
- MedicineCritical Care Medicine
- 1 July 2004
The data from this study indicate that an early decrease in protein C concentration predicts poor outcome in a rat sepsis model and indicates that increases in the CXC chemokines macrophage inflammatory protein-2 and KC precede poor outcome.
Homeotic genes have specific functional roles in the establishment of the Drosophila embryonic peripheral nervous system.
- J. G. Heuer, T. Kaufman
- 1 May 1992
The results are suggestive of a role for the homeotic gene products in regulating genes which are necessary for generating sensory progenitor cells in the developing PNS.