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A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial–mesenchymal transition
TLDR
It is proposed that activation of a SNAIL1–SMAD3/4 transcriptional complex represents a mechanism of gene repression during EMT, which is essential for organogenesis and is triggered during carcinoma progression to an invasive state. Expand
Functionally specialized junctions between endothelial cells of lymphatic vessels
TLDR
It is suggested that fluid enters throughoutInitial lymphatics via openings between buttons, which open and close without disrupting junctional integrity, but most leukocytes enter the proximal half of initial lymphatics. Expand
Functionally specialized junctions between endothelial cells of lymphatic vessels
Baluk et al. 2007. J. Exp. Med. doi:10.1084/jem.20062596[OpenUrl][1][Abstract/FREE Full Text][2] [1]:Expand
Transcriptional crosstalk between TGFβ and stem cell pathways in tumor cell invasion: Role of EMT promoting Smad complexes
TLDR
Current understanding of the mechanisms involved in the transcriptional crosstalk between TGF-β and stem cell pathways are reviewed and how a fundament for the activation of these mechanisms may lead to the induction of EMT in tumors is discussed. Expand
Guidelines and definitions for research on epithelial–mesenchymal transition
TLDR
This Consensus Statement is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications to reduce misunderstanding and misinterpretation of research data generated in various experimental models. Expand
The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2.
TLDR
It is shown that S1PR1, a receptor for the blood-borne bioactive lipid sphingosine-1-phosphate (S1P), is critical for inhibition of angiogenesis and acquisition of vascular stability, and suggested that it acts as a vascular-intrinsic stabilization mechanism, protecting developing blood vessels against aberrant angiogenic responses. Expand
Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis.
TLDR
It is found that the pattern recognition scavenger receptor MARCO defines a subtype of suppressive TAMs and is linked to clinical outcome, and it is demonstrated that immunotherapies using antibodies designed to modify myeloid cells of the TME represent a promising mode of cancer treatment. Expand
Induction of neutrophil gelatinase-associated lipocalin in vascular injury via activation of nuclear factor-kappaB.
TLDR
A previously unrecognized vascular response to an-gioplastic injury is revealed, characterized by NF-kappaB-dependent expression of NGAL in vascular SMCs, and SMC-produced NGAL interacts with MMP-9, a mechanism by which NGAL may modulate M MP-9 proteolytic activity in the vascular repair process. Expand
The coxsackie- and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis.
TLDR
It is concluded that CAR is localized to epithelial tight junctions in vivo where it may play a role in the regulation of epithelial permeability and tissue homeostasis. Expand
CLMP, a Novel Member of the CTX Family and a New Component of Epithelial Tight Junctions*
TLDR
CLMP is a novel cell-cell adhesion molecule and a new component of epithelial tight junctions and it is suggested that CLMP, CAR, ESAM, and BT-IgSF form a new group of proteins within the CTX family. Expand
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